Huang Zining, Hu Linqing, Liu Zhiwei, Wang Shanshan
State Key Laboratory of Biocatalysis and Enzyme Engineering, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, School of Life Sciences, Hubei University, Wuhan 430062, China.
Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China.
Int J Mol Sci. 2025 Apr 12;26(8):3644. doi: 10.3390/ijms26083644.
Skeletal muscle development is a complex biological process regulated by many factors, such as transcription factors, signaling pathways, and epigenetic modifications. Histone modifications are important epigenetic regulatory factors involved in various biological processes, including skeletal muscle development, and play a crucial role in the pathogenesis of skeletal muscle diseases. Histone modification regulators affect the expression of many genes involved in skeletal muscle development and disease by adding or removing certain chemical modifications. In this review, we comprehensively summarize the functions and regulatory activities of the histone modification regulators involved in skeletal muscle development, regeneration, and disease.
骨骼肌发育是一个由许多因素调控的复杂生物学过程，这些因素包括转录因子、信号通路和表观遗传修饰。组蛋白修饰是参与包括骨骼肌发育在内的各种生物学过程的重要表观遗传调控因子，并且在骨骼肌疾病的发病机制中发挥关键作用。组蛋白修饰调节剂通过添加或去除某些化学修饰来影响许多参与骨骼肌发育和疾病的基因的表达。在本综述中，我们全面总结了参与骨骼肌发育、再生和疾病的组蛋白修饰调节剂的功能和调控活性。
