Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangdong Second Provincial General Hospital, Guangzhou, China.
Department of Radiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Acta Physiol (Oxf). 2020 Feb;228(2):e13356. doi: 10.1111/apha.13356. Epub 2019 Aug 19.
The multistep biological process of myogenesis is regulated by a variety of myoblast regulators, such as myogenic differentiation antigen, myogenin, myogenic regulatory factor, myocyte enhancer factor2A-D and myosin heavy chain. Proliferation and differentiation during skeletal muscle myogenesis contribute to the physiological function of muscles. Certain non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are involved in the regulation of muscle development, and the aberrant expressions of lncRNAs and circRNAs are associated with muscular diseases. In this review, we summarize the recent advances concerning the roles of lncRNAs and circRNAs in regulating the developmental aspects of myogenesis. These findings have remarkably broadened our understanding of the gene regulation mechanisms governing muscle proliferation and differentiation, which makes it more feasible to design novel preventive, diagnostic and therapeutic strategies for muscle disorders.
肌发生的多步骤生物学过程受多种成肌细胞调节因子的调节，如成肌分化抗原、成肌因子、肌调节因子、肌细胞增强因子 2A-D 和肌球蛋白重链。在骨骼肌发生过程中的增殖和分化有助于肌肉的生理功能。某些非编码 RNA，包括长非编码 RNA（lncRNA）和环状 RNA（circRNA），参与肌肉发育的调节，lncRNA 和 circRNA 的异常表达与肌肉疾病有关。在这篇综述中，我们总结了 lncRNA 和 circRNA 在调节肌发生发育方面的作用的最新进展。这些发现极大地拓宽了我们对调控肌肉增殖和分化的基因调控机制的理解，为设计肌肉疾病的新型预防、诊断和治疗策略提供了更多的可能性。
