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甲状腺癌中 、 和 作为预后生物标志物的上调：一项泛癌和TCGA数据分析

Upregulation of , , and as Prognostic Biomarkers in Thyroid Cancer: A Pan-Cancer and TCGA Data Analysis.

作者信息

Zhu Nuoyan, Cai Liangliang, Qian Li

机构信息

Medical College, Yangzhou University, Yangzhou 225012, China.

出版信息

Int J Mol Sci. 2025 Apr 20;26(8):3887. doi: 10.3390/ijms26083887.

DOI:10.3390/ijms26083887
PMID:40332815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12027860/
Abstract

The study of gene anomalies linked to thyroid cancer is gaining more and more attention, and these molecular indicators can offer scholarly support for thyroid cancer diagnosis, therapy selection, and prognosis. Genotype-tissue expression pan-cancer data and The Cancer Genome Atlas (TCGA) were used to investigate the expression of , , and . In order to assess the relationship between , , and expression and patient outcome, TCGA clinical survival data were used. We used the clusterProfiler R software tool to conduct enrichment analysis of , , and . Moreover, TCGA database analysis was used to assess the relationship between immune cell infiltration and , , and expression. , , and were strongly expressed in several kinds of malignancies including thyroid cancer. Gene sets related to proliferation that are involved in leukocyte cell-cell adhesion and mononuclear cell differentiation were significantly correlated with high expression of , , and . Additional investigation revealed a correlation between high T cell and DC (dendritic cell) infiltration scores and high expression of , , and . According to our research, , , and could all be genes associated with thyroid cancer.

摘要

与甲状腺癌相关的基因异常研究正受到越来越多的关注，这些分子指标可为甲状腺癌的诊断、治疗选择及预后提供学术支持。利用基因型-组织表达泛癌数据和癌症基因组图谱（TCGA）来研究[具体基因1]、[具体基因2]和[具体基因3]的表达情况。为了评估[具体基因1]、[具体基因2]和[具体基因3]的表达与患者预后之间的关系，使用了TCGA临床生存数据。我们使用clusterProfiler R软件工具对[具体基因1]、[具体基因2]和[具体基因3]进行富集分析。此外，利用TCGA数据库分析来评估免疫细胞浸润与[具体基因1]、[具体基因2]和[具体基因3]表达之间的关系。[具体基因1]、[具体基因2]和[具体基因3]在包括甲状腺癌在内的多种恶性肿瘤中高表达。与增殖相关的基因集，涉及白细胞细胞间黏附和单核细胞分化，与[具体基因1]、[具体基因2]和[具体基因3]的高表达显著相关。进一步研究发现高T细胞和树突状细胞（DC）浸润评分与[具体基因1]、[具体基因2]和[具体基因3]的高表达之间存在相关性。根据我们的研究，[具体基因1]、[具体基因2]和[具体基因3]都可能是与甲状腺癌相关的基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/f1e954340930/ijms-26-03887-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/6932c14fcf7b/ijms-26-03887-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/5347cf34717b/ijms-26-03887-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/758e18c9cc58/ijms-26-03887-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/599d74a45a51/ijms-26-03887-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/f1e954340930/ijms-26-03887-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/6932c14fcf7b/ijms-26-03887-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/5347cf34717b/ijms-26-03887-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/758e18c9cc58/ijms-26-03887-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/599d74a45a51/ijms-26-03887-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f5/12027860/f1e954340930/ijms-26-03887-g005.jpg

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Nature. 2025 Feb;638(8050):490-498. doi: 10.1038/s41586-024-08395-9. Epub 2025 Jan 15.
2
TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy.TREM2 缺乏重编程肠道巨噬细胞和微生物群，以增强抗 PD-1 肿瘤免疫治疗。
Sci Immunol. 2024 May 17;9(95):eadi5374. doi: 10.1126/sciimmunol.adi5374.
3
Thyroid Cancer: A Review.甲状腺癌：综述。
JAMA. 2024 Feb 6;331(5):425-435. doi: 10.1001/jama.2023.26348.
4
TREM2: A new player in the tumor microenvironment.触发受体表达于髓细胞2（TREM2）：肿瘤微环境中的新角色
Semin Immunol. 2023 May;67:101739. doi: 10.1016/j.smim.2023.101739. Epub 2023 Mar 28.
5
Role of the granzyme family in rheumatoid arthritis: Current Insights and future perspectives.颗粒酶家族在类风湿关节炎中的作用：当前的认识和未来的展望。
Front Immunol. 2023 Feb 16;14:1137918. doi: 10.3389/fimmu.2023.1137918. eCollection 2023.
6
Thyroid cancer, recent advances in diagnosis and therapy.甲状腺癌：诊断与治疗的新进展。
Int J Cancer. 2021 Sep 1;149(5):984-992. doi: 10.1002/ijc.33690. Epub 2021 May 29.
7
TREM2, microglia, and Alzheimer's disease.TREM2、小胶质细胞与阿尔茨海默病。
Mech Ageing Dev. 2021 Apr;195:111438. doi: 10.1016/j.mad.2021.111438. Epub 2021 Jan 28.
8
Immunotherapy in NSCLC patients with brain metastases. Understanding brain tumor microenvironment and dissecting outcomes from immune checkpoint blockade in the clinic.非小细胞肺癌脑转移患者的免疫治疗。了解脑肿瘤微环境并剖析临床免疫检查点阻断治疗的结果。
Cancer Treat Rev. 2020 Sep;89:102067. doi: 10.1016/j.ctrv.2020.102067. Epub 2020 Jul 7.
9
Prognostic Role of Immune Markers in Triple Negative Breast Carcinoma.免疫标志物在三阴性乳腺癌中的预后作用。
Pathol Oncol Res. 2020 Oct;26(4):2733-2745. doi: 10.1007/s12253-020-00874-4. Epub 2020 Jul 17.
10
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects.肿瘤微环境中的调节性 T 细胞：新机制、潜在治疗策略和未来前景。
Mol Cancer. 2020 Jul 17;19(1):116. doi: 10.1186/s12943-020-01234-1.