Izzo J L, Thompson D A, Horwitz D
Life Sci. 1985 Sep 16;37(11):1033-8. doi: 10.1016/0024-3205(85)90593-4.
We investigated the utility of deaminated norepinephrine (NE) metabolites in the study of human sympathetic nervous pathophysiology. Plasma levels of the NE metabolite dihydroxyphenylglycol (DHPG) appear to be related to intraneuronal NE stores. Plasma DHPG increases when sympathetic nervous activity or circulating NE increase and decreases when neuronal NE is depleted or neuronal NE reuptake is blocked. Changes in plasma dihydroxymandelic acid (DOMA) related less closely to changes in plasma NE. The coupling of measurements of plasma NE with its deaminated metabolites and DHPG may improve understanding of human NE metabolism and neuronal NE reuptake.
我们研究了脱氨基去甲肾上腺素（NE）代谢产物在人类交感神经病理生理学研究中的效用。NE代谢产物二羟基苯乙二醇（DHPG）的血浆水平似乎与神经元内NE储备有关。当交感神经活动或循环中的NE增加时，血浆DHPG升高；而当神经元NE耗尽或神经元NE再摄取受阻时，血浆DHPG降低。血浆二羟基扁桃酸（DOMA）的变化与血浆NE的变化相关性较小。将血浆NE与其脱氨基代谢产物及DHPG的测量结果相结合，可能会增进对人类NE代谢及神经元NE再摄取的理解。
