TaMoNbTiZr Multielement Alloy for Medical Instruments.

In this paper, a new TaMoNbTiZr multielement alloy has been designed, using chemical elements that exhibit extremely low bio-toxicity for the human body. The alloy was obtained by melting in vacuum arc remelting (VAR) equipment MRF ABJ 900 from high-purity chemical elements (99.5%) as mini-ingots having about 40 g weight each. The biocompatible alloys underwent changes in hardness after performing the annealing at 900 °C for 2 h, followed by cooling in water. The new alloy had an average hardness in the cast state of 545 HV0.5, and after heat treatment, it hardened to a value of 984 HV0.5, over 40% higher than that in the casting state, which ensures a longer working period. To use them as materials for medical instruments, their biocompatibility was highlighted through specific laboratory tests. For this, mesenchymal stem cells isolated from bone tissue and a human fibroblast cell line were cultured in vitro on the TaMoNbTiZr alloy's surface. The biocompatibility of the alloy with the biological environment was evaluated by analyzing cell viability, adhesion, and proliferation, and in parallel, the cytolysis effects manifested by the increase in lactate dehydrogenase activity in the culture media were analyzed.