Bioactive Secondary Metabolites from an Arctic Marine-Derived Strain, sp. MNP-1, Using the OSMAC Strategy.

An Arctic marine-derived strain, MNP-1, was characterized by a combined methodological approach, incorporating a variety of analytical techniques including morphological features, biochemical characteristics, and 16S ribosomal RNA (rRNA) sequence analysis. The chemical investigation of sp. MNP-1 using the OSMAC (one strain many compounds) strategy yielded the isolation of twenty known compounds (), which were unambiguously identified by various spectroscopic approaches including H and C NMR and ESI-MS (previously reported data). Bioassay results indicated that compounds , , , , , , and had antimicrobial activity against human pathogenic strains including , , and with MIC values ranging from 4 to 32 μg/mL, and compounds and exhibited moderate inhibitory activity on A549, MCF-7, and HepG2 tumor lines showing IC values within the range of 19.88 to 35.82 µM. These findings suggest that sp. MNP-1 is one of the prolific manufacturers of bioactive secondary metabolites with therapeutic potential.