古老的细胞因子，新的作用方式：干扰素抗病毒活性的优化模型
Old cytokine, new tricks: A refined model of interferon's antiviral activity.
作者信息
Schoggins John W
机构信息
Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, United States of America.
出版信息
PLoS Biol. 2025 May 7;23(5):e3003154. doi: 10.1371/journal.pbio.3003154. eCollection 2025 May.
Abstract
Interferon is a central component of the vertebrate antiviral immune response, thought to act through induction of hundreds of interferon-stimulated genes, with some redundancy. Recent findings suggest a more refined 'limited set' model, in which distinct viruses are targeted by small subsets of the induced gene repertoire.
摘要
干扰素是脊椎动物抗病毒免疫反应的核心组成部分，被认为通过诱导数百种干扰素刺激基因发挥作用，存在一定冗余。最近的研究结果提出了一种更为精细的“有限集”模型，即诱导基因库中的小子集针对不同的病毒。
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