Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.
Nat Rev Immunol. 2013 Jan;13(1):46-57. doi: 10.1038/nri3344. Epub 2012 Dec 14.
Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families--the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
在过去的几年中，有几个研究小组已经确定了新型基因，这些基因在 I 型干扰素 (IFN) 信号转导的下游被转录诱导，并且可以抑制单个或多种病毒家族的感染。在具有抗病毒活性的 IFN 诱导基因中，有两个在遗传和功能上不同的家族——具有四肽重复的 IFN 诱导蛋白 (IFIT) 家族和 IFN 诱导跨膜蛋白 (IFITM) 家族。这篇综述主要关注最近在鉴定 IFIT 和 IFITM 蛋白的独特作用机制方面的进展，这些机制解释了它们对一系列人类病毒的复制、传播和发病机制的广谱活性。
