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来自……种子的体外抗炎萜类糖苷 。 （你提供的原文不完整，“from the Seeds of.”后面缺少具体植物名称等信息）

In Vitro Anti-Inflammatory Terpenoid Glycosides from the Seeds of .

作者信息

Zhang Wei, Ruan Jingya, Cheng Jiaming, Wang Yingying, Zheng Yinuo, Lin Minghao, Zhang Yi, Wang Tao

机构信息

Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.

Institute of Tianjin University of Traditional Chinese, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.

出版信息

Molecules. 2025 Apr 15;30(8):1779. doi: 10.3390/molecules30081779.

DOI:10.3390/molecules30081779
PMID:40333725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12029661/
Abstract

To further explore the anti-inflammatory components of the seeds of L., a comprehensive phytochemical investigation was conducted using diverse chromatographic and spectrometric technologies, as well as chemical reactions. As a result, ten previously unreported terpenoid glycosides, namely dolilabterpenosides A, B, C-C, D, E, and F-F (-), along with four known analogues (-), initially identified from genus, were obtained. In addition, the lipopolysaccharide (LPS)-induced RAW264.7 cell model was employed to detect the expression levels of nitric oxide (NO), inflammatory cytokines tumour necrosis factor (TNF)-α and interleukin (IL)-1β to assess the anti-inflammatory activities of the obtained compounds. The results of bioactive assay showed that compounds , -, and - showed significant inhibitory activity on NO release in RAW264.7 cells in a dose-dependent manner, and all of them were demonstrated to inhibit the increase in TNF-α and IL-Iβ levels in the supernatant of RAW264.7 cells stimulated by LPS.

摘要

为了进一步探索某植物种子的抗炎成分，采用了多种色谱和光谱技术以及化学反应进行了全面的植物化学研究。结果，从该植物属中获得了十种先前未报道的萜类糖苷，即多利拉萜糖苷A、B、C - C、D、E和F - F（-），以及四种已知类似物（-）。此外，利用脂多糖（LPS）诱导的RAW264.7细胞模型检测一氧化氮（NO）、炎性细胞因子肿瘤坏死因子（TNF）-α和白细胞介素（IL）-1β的表达水平，以评估所获化合物的抗炎活性。生物活性测定结果表明，化合物 、 - 和 - 对RAW264.7细胞中NO的释放具有显著的剂量依赖性抑制活性，并且所有这些化合物均被证明可抑制LPS刺激的RAW264.7细胞上清液中TNF-α和IL - Iβ水平的升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/e82b87635eb7/molecules-30-01779-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/89d09b2b59e7/molecules-30-01779-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/d5dadc1d8cdd/molecules-30-01779-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/6266eaae1dd0/molecules-30-01779-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/8052bdfaa2ad/molecules-30-01779-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/1abdc0959bf8/molecules-30-01779-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/62f53fd5f5b0/molecules-30-01779-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/e82b87635eb7/molecules-30-01779-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/89d09b2b59e7/molecules-30-01779-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/d5dadc1d8cdd/molecules-30-01779-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/6266eaae1dd0/molecules-30-01779-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/8052bdfaa2ad/molecules-30-01779-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/1abdc0959bf8/molecules-30-01779-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/62f53fd5f5b0/molecules-30-01779-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bc/12029661/e82b87635eb7/molecules-30-01779-g007.jpg

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本文引用的文献

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Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities.
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