State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Fitoterapia. 2023 Dec;171:105694. doi: 10.1016/j.fitote.2023.105694. Epub 2023 Sep 29.
Twenty-four aromatic compounds including five novel ones, dolilabphenosides A (1), B (2), B (3), C (4), and C (5) were obtained from the seeds of Dolichos lablab L. Their structures were established based on spectroscopic analyses and chemical reactions. Among the known compounds, 9, 10, 14, 17, 19, and 22-24 were gained from the family Leguminosae for the first time, and 6, 8, 11-13, 15, 16, 18, 20, as well as 21 were firstly identified from Dolichos genus. Moreover, the inhibitory effect evaluation of all the isolates against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages suggested that compounds 1-3, 6, 7, 11-15, 17, 20, 21, 23, 24 exhibited anti-inflammatory activity in a concentration-dependent manner. Moreover, the novel compounds, dolilabphenosides A (1), B (2), B (3) were found to inhibit the secretion of inflammatory cytokine IL-1β.
从豇豆种子中分离得到 24 种芳香族化合物，包括 5 种新化合物，即 dolilabphenosides A（1）、B（2）、B（3）、C（4）和 C（5）。根据光谱分析和化学反应确定了它们的结构。在已知化合物中，9、10、14、17、19 和 22-24 是首次从豆科中获得的，而 6、8、11-13、15、16、18、20 以及 21 是首次从豇豆属中鉴定得到的。此外，所有分离物对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮（NO）产生的抑制作用评价表明，化合物 1-3、6、7、11-15、17、20、21、23、24 呈浓度依赖性抑制炎症作用。此外，新型化合物 dolilabphenosides A（1）、B（2）、B（3）被发现可抑制炎症细胞因子 IL-1β 的分泌。
