Zheng Chaoshun, Zhang Longsheng, Guo Yueyue, Lin Chuchun, He Xuhui
Department of Orthopedics II, Jieyang People's Hospital, Jieyang, China.
Department of anesthesiology, Jieyang People's Hospital, Jieyang, China.
PLoS One. 2025 May 7;20(5):e0323228. doi: 10.1371/journal.pone.0323228. eCollection 2025.
The Alternative Healthy Eating Index (AHEI-2010) is a dietary index associated with chronic diseases and serves as an important metric for assessing the healthiness of one's diet. Serum Soluble Klotho (S-Klotho) is a protein related to anti-aging. There is currently a lack of research on the relationship between AHEI and S-Klotho. This study evaluated the relationship between the AHEI index and S-Klotho in the U.S. middle-aged and elderly population from the National Health and Nutrition Examination Survey (NHANES) 2011-2016.
This study includes 6,305 middle-aged and elderly participants (aged 40-79 years old). The interrelationship between the AHEI-2010 and S-klotho concentration was explored using multivariate regression models, and the nonlinear relationship between the two was investigated through curve fitting. The stability of this relationship in different populations was explored through subgroup analysis.
There was a positive correlation between AHEI and S-klotho (β=1.1, 95% CI: 0.1, 2.1, P = 0.035). The multivariate-adjusted β and 95% confidence intervals (CIs) from the lowest to the highest AHEI-2010 categories (＜31.9, 31.9-39.3, 39.3-47.9, and > 47.9) were 0.0 (reference), 15.7 (-13.5, 44.9), 12.5 (-16.5, 41.6), and 31.9 (2.9, 60.9), respectively. The curve fitting found that the relationship between AHEI-2010 and S-Klotho is essentially linear, with S-Klotho levels increasing linearly as AHEI improves.
AHEI is positively associated with S-Klotho levels in American middle-to-older adults. Further research is needed to elucidate the causal relationship and specific mechanisms.
替代健康饮食指数（AHEI-2010）是一种与慢性疾病相关的饮食指数，是评估个人饮食健康程度的重要指标。血清可溶性α-klotho蛋白（S-Klotho）是一种与抗衰老相关的蛋白质。目前关于AHEI与S-Klotho之间关系的研究较少。本研究利用2011-2016年美国国家健康与营养检查调查（NHANES）评估了美国中老年人群中AHEI指数与S-Klotho之间的关系。
本研究纳入6305名中老年参与者（年龄40-79岁）。使用多元回归模型探讨AHEI-2010与S-klotho浓度之间的相互关系，并通过曲线拟合研究两者之间的非线性关系。通过亚组分析探讨这种关系在不同人群中的稳定性。
AHEI与S-klotho呈正相关（β=1.1，95%CI：0.1，2.1，P = 0.035）。从最低到最高AHEI-2010类别（＜31.9、31.9-39.3、39.3-47.9和＞47.9）的多元调整β和95%置信区间（CI）分别为0.0（参考值）、15.7（-13.5，44.9）、12.5（-16.5，41.6）和31.9（2.9，60.9）。曲线拟合发现，AHEI-2010与S-Klotho之间的关系基本呈线性，随着AHEI的改善，S-Klotho水平呈线性增加。
在美国中老年人群中，AHEI与S-Klotho水平呈正相关。需要进一步研究以阐明因果关系和具体机制。
