Yan Dan
Department of Pulmonary and Critical Care Medicine, Jinhua Municipal Central Hospital, The Affiliated Jinhua Hospital, College of Medicine, Zhejiang University, Jinhua, China.
Front Med (Lausanne). 2024 Jul 18;11:1361922. doi: 10.3389/fmed.2024.1361922. eCollection 2024.
Chronic obstructive pulmonary disease (COPD) is accompanied by increased inflammation, persistent lung function decline, and extensive lung injury. Klotho, a well-known antiaging protein, has anti-inflammatory and antioxidative effects. However, the effects of klotho on COPD have yet to be thoroughly elucidated. This study examined the association among COPD adults and their α-klotho level.
Data were collected from the 2007 to 2012 National Health and Nutrition Examination Survey (NHANES). A total of 676 participants were analyzed and divided into COPD ( = 403) and non-COPD ( = 273) groups. The two groups were compared with respect to clinical characteristics. Logistic regression analysis and a generalized additive model were used to estimate the association between COPD incidence and serum α-klotho concentration. All COPD participants were stratified according to the levels of α-klotho (Q1: <687 pg./mL; Q2: 687-900 pg./mL; Q3: ≥900 pg./mL), and clinical characteristics were compared.
Non-COPD individuals had higher α-klotho levels than did COPD individuals (863.09 ± 267.13 vs. 817.51 ± 302.20, < 0.05). Logistic regression analysis revealed that the Q2 and Q3 layers had a lower risk of COPD than did the Q1 layer, with odds ratios (ORs) of 0.73 (0.50, 0.99) for Q2 and 0.58 (0.41, 0.86) for Q3 ( < 0.001). The generalized additive model showed that the risk of COPD gradually decreased with increasing α-klotho concentration when the α-klotho concentration < 1,500 pg./mL, while the risk of COPD increased as the α-klotho concentration increased to ≥1,500 pg./mL. Compared with individuals in the Q2 or Q3 groups, individuals with COPD in the Q1 group were more likely to be current smokers, have lower levels of erythrocytes, and have higher levels of creatinine and leukocytes.
Increased α-klotho levels were negatively correlated with the risk of COPD in participants over 40 years old with α-klotho <1,500 pg./mL. When α-klotho was ≥1,500 pg./mL, the risk of COPD increased as α-klotho levels increased. Pulmonary ventilation function and the number of hemocytes differed among COPD patients with different levels of α-klotho.
慢性阻塞性肺疾病（COPD）伴有炎症增加、肺功能持续下降和广泛的肺损伤。α-klotho是一种著名的抗衰老蛋白，具有抗炎和抗氧化作用。然而，α-klotho对COPD的影响尚未完全阐明。本研究探讨了COPD成人与其α-klotho水平之间的关联。
数据收集自2007年至2012年美国国家健康与营养检查调查（NHANES）。共分析676名参与者，并分为COPD组（n = 403）和非COPD组（n = 273）。比较两组的临床特征。采用逻辑回归分析和广义相加模型来估计COPD发病率与血清α-klotho浓度之间的关联。所有COPD参与者根据α-klotho水平分层（Q1：<687 pg/mL；Q2：687 - 900 pg/mL；Q3：≥900 pg/mL），并比较临床特征。
非COPD个体的α-klotho水平高于COPD个体（863.09 ± 267.13 vs. 817.51 ± 302.20，P < 0.05）。逻辑回归分析显示，Q2和Q3层患COPD的风险低于Q1层，Q2的比值比（OR）为0.73（0.50，0.99），Q3为0.58（0.41，0.86）（P < 0.001）。广义相加模型显示，当α-klotho浓度<1,500 pg/mL时，COPD风险随α-klotho浓度增加而逐渐降低，而当α-klotho浓度增加到≥1,500 pg/mL时，COPD风险增加。与Q2或Q3组个体相比，Q1组的COPD个体更可能是当前吸烟者，红细胞水平较低，肌酐和白细胞水平较高。
在40岁以上且α-klotho<1,500 pg/mL的参与者中，α-klotho水平升高与COPD风险呈负相关。当α-klotho≥1,500 pg/mL时，COPD风险随α-klotho水平升高而增加。不同α-klotho水平的COPD患者肺通气功能和血细胞数量存在差异。
