Banerjee Pradipta, Das Arpan, Kumar Pawan, Chakraborty Sanjoy, Jalan Komal
Department of Surgery, University of Pittsburgh, Pittsburgh,Pennsylvania, USA.
Department of Biochemistry, Centurion University of Technology and Management, Paralakhemundi, Odisha, India.
J Am Nutr Assoc. 2025 May 7:1-12. doi: 10.1080/27697061.2025.2496945.
, more famous as Shatavari, is a popular medicinal plant with a broad species distribution across the Indian subcontinent as well as across the globe. The multidimensional therapeutic potential of this herb has earned it the title of "Queen of Herbs." Shatavari is rich in bioactive constituents including alkaloids, carboxylic acids, polycyclic hydrocarbons, isoflavones, flavonoids, dihydrophenanthrene derivatives, furan derivatives, essential oils, sterols, and steroidal saponin (specifically Shatavarin-I to VI), distributed throughout the rhizome as well as in other parts of the plant. These compounds are frequently used in the treatment of several medical conditions, including dysentery, diabetic retinopathy, hypertension, anxiety disorders, inflammation, tumors, mental disorders, hyperacidity, viral diseases, spasms, chronic fever, and rheumatism. In addition, Shatavari possesses antibacterial, adaptogenic, and antioxidant properties. Shatavarin IV, a sarsapogenin enriched in the roots of Shatavari, is especially beneficial for women's reproductive health and also acts as an effective stressbuster. It is used as a remedy for female infertility by boosting libido, managing sexual organ inflammation, facilitating folliculogenesis and ovulation, preparing the uterus for conception, preventing miscarriages, functioning as a postpartum tonic by enhancing lactation and restoring uterine and hormonal homeostasis. In this regard, a novel Asparagus root formulation, Shevari4T has been developed, with Shatavarin IV content exceeding 7.4%, which promises to deliver the goodness of Shatavari, especially for women. This review provides a comprehensive insight into the holistic health benefits of Shatavari, with particular emphasis on Shatavarin IV.Key teaching pointsAsparagus racemosus (Shatavari) is a perennial climber medicinal plant containing multiple bioactive constituents including selected steroidal saponins, namely, Shatavarin I - VI.Shatavarin I and Shatavarin IV are the most potent glycosides found in abundance in the roots of the plant.Shatavarin IV is comprising of two molecules of rhamnose and one glucose molecule, and basically it is a glycoside of sarsasapogenin.Shatavarin IV, a steroidal saponin from Asparagus racemosus, exhibits potent pharmacological effects including antioxidant, anti-cancer, anti-inflammatory, cardioprotective, immunomodulatory, neuroprotective, antibacterial, antidiabetic and antihypertensive properties.It also augments female fertility and reproduction by facilitating folliculogenesis and ovulation, preparing the uterus for conception, preventing miscarriages, functioning as a postpartum tonic by enhancing lactation and restoring uterine and hormonal homeostasis.
作为沙塔瓦里更为人所知，是一种广受欢迎的药用植物，在印度次大陆以及全球都有广泛的物种分布。这种草药的多维治疗潜力为它赢得了“草药女王”的称号。沙塔瓦里富含生物活性成分，包括生物碱、羧酸、多环烃、异黄酮、黄酮类化合物、二氢菲衍生物、呋喃衍生物、精油、甾醇和甾体皂苷（特别是沙塔瓦林 - I至VI），分布在根茎以及植物的其他部位。这些化合物常用于治疗多种疾病，包括痢疾、糖尿病视网膜病变、高血压、焦虑症、炎症、肿瘤、精神障碍、胃酸过多、病毒性疾病、痉挛、慢性发热和风湿病。此外，沙塔瓦里具有抗菌、适应原性和抗氧化特性。沙塔瓦林IV是一种富含在沙塔瓦里根部的菝葜皂苷元，对女性生殖健康特别有益，也是一种有效的减压剂。它通过增强性欲、治疗性器官炎症、促进卵泡生成和排卵、为受孕准备子宫、预防流产、通过促进泌乳和恢复子宫及激素平衡起到产后滋补剂的作用，从而被用作治疗女性不孕症的药物。在这方面，已经开发出一种新型芦笋根制剂Shevari4T，其沙塔瓦林IV含量超过7.4%，有望带来沙塔瓦里的益处，特别是对女性。本综述全面深入地探讨了沙塔瓦里对整体健康的益处，尤其强调了沙塔瓦林IV。
关键知识点
印度天门冬（沙塔瓦里）是一种多年生攀缘药用植物，含有多种生物活性成分，包括选定的甾体皂苷，即沙塔瓦林I - VI。
沙塔瓦林I和沙塔瓦林IV是在该植物根部大量发现的最有效的糖苷。
沙塔瓦林IV由两个鼠李糖分子和一个葡萄糖分子组成，基本上是菝葜皂苷元的糖苷。
沙塔瓦林IV是一种来自印度天门冬的甾体皂苷，具有强大的药理作用，包括抗氧化、抗癌、抗炎、心脏保护、免疫调节、神经保护、抗菌、抗糖尿病和抗高血压特性。
它还通过促进卵泡生成和排卵、为受孕准备子宫、预防流产、通过促进泌乳和恢复子宫及激素平衡起到产后滋补剂的作用，从而增强女性生育能力和生殖功能。
