Wang Chen-Chi, Wang Wei-Xiang, Wu Po-Yuan
Department of Medical Education, China Medical University Hospital, Taichung, Taiwan.
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
PLoS One. 2025 May 7;20(5):e0323051. doi: 10.1371/journal.pone.0323051. eCollection 2025.
Zinc plays a crucial role in maintaining immune balance in the human body. Zinc is believed to substantially affect cytokine synthesis and signaling; thus potentially combating viral infections, including Human Papillomavirus infection, through various mechanisms. Several randomized controlled trials (RCTs) have investigated whether oral zinc sulphate can improve viral warts; however, no comprehensive data is currently available. Therefore, we conducted a meta-analysis to evaluate the effectiveness of oral zinc sulphate for the treatment of viral warts. On July 1, 2024, we performed an extensive database search on PubMed, Embase, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov. Initially, 952 studies were identified, and after screening, 7 studies were included in the final analysis. Our findings showed that the total clearance rate of warts was significantly higher in the oral zinc sulphate group than in the control group (risk difference = 0.288; 95% CI = 0.087-0.489; p = 0.005). Subgroup analysis revealed that this therapeutic effect was more pronounced in individuals with low initial plasma zinc levels (risk difference = 0.767; 95% CI = 0.649-0.885; p < 0.001). Additionally, meta-regression showed that rise in zinc ion levels post-treatment were correlated with better treatment outcomes (coefficient = 0.0068; p < 0.001). Furthermore, for patients receiving traditional warts treatment, combining oral zinc sulphate significantly reduced the 6-month recurrence rate (log risk ratio = -1.043; 95% CI = -1.666 - -0.420; p = 0.001). The most common treatment-related side effects were nausea (risk difference = 0.562; 95% CI = 0.088-1.036; p = 0.020) and vomiting (risk difference = 0.205; 95% CI = 0.092-0.317; p < 0.001). Based on this evidence, oral zinc sulphate monotherapy offers notable benefits to those avoiding conventional treatments, and when combined with traditional therapies for viral warts, it can notably reduce recurrence rates over six months.
锌在维持人体免疫平衡方面起着至关重要的作用。锌被认为会对细胞因子的合成和信号传导产生重大影响；因此，它可能通过多种机制对抗病毒感染，包括人乳头瘤病毒感染。多项随机对照试验（RCT）研究了口服硫酸锌是否能改善病毒疣；然而，目前尚无全面的数据。因此，我们进行了一项荟萃分析，以评估口服硫酸锌治疗病毒疣的有效性。2024年7月1日，我们在PubMed、Embase、科学网、Cochrane CENTRAL和ClinicalTrials.gov上进行了广泛的数据库搜索。最初，共识别出952项研究，经过筛选，最终分析纳入了7项研究。我们的研究结果表明，口服硫酸锌组的疣体总清除率显著高于对照组（风险差异=0.288；95%置信区间=0.087-0.489；p=0.005）。亚组分析显示，这种治疗效果在初始血浆锌水平较低的个体中更为明显（风险差异=0.767；95%置信区间=0.649-0.885；p<0.001）。此外，荟萃回归显示，治疗后锌离子水平的升高与更好的治疗结果相关（系数=0.0068；p<0.001）。此外，对于接受传统疣治疗的患者，联合口服硫酸锌可显著降低6个月的复发率（对数风险比=-1.043；95%置信区间=-1.666--0.420；p=0.001）。最常见的与治疗相关的副作用是恶心（风险差异=0.562；95%置信区间=0.088-1.036；p=0.020）和呕吐（风险差异=0.205；95%置信区间=0.092-0.317；p<0.001）。基于这些证据，口服硫酸锌单一疗法对那些避免传统治疗的人有显著益处，并且当与病毒疣的传统疗法联合使用时，它可以显著降低六个月内的复发率。
Zotero 插件
