全球人类肠道腺病毒感染患病率的系统评价与荟萃分析。
A systematic review and meta-analysis of the global prevalence of human enteric adenovirus infections.
作者信息
Wikswo Mary E, Kambhampati Anita K, Mattison Claire P, Chhabra Preeti, Olojo Oluwatosin, Rana Taha, Vinjé Jan, Kirkwood Carl D, Parashar Umesh D, Mirza Sara A
机构信息
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA.
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA; Cherokee Nation Operational Solutions, 2 W. 2nd St., Suite 1500, Tulsa, OK 74103, USA.
出版信息
J Infect Public Health. 2025 Jul;18(7):102800. doi: 10.1016/j.jiph.2025.102800. Epub 2025 May 2.
Human adenovirus (HAdV), especially HAdV species F (HAdV-F) is recognized as a cause of acute gastroenteritis (AGE) worldwide. To assess the global prevalence of HAdV in case-patients of all ages with AGE, we conducted a systematic literature search for studies published in English during 2015-2022. We generated pooled prevalence estimates using generalized linear mixed models. Using data from 147 included articles, the overall pooled prevalence among AGE case-patients of any species of HAdV (pan-HAdV) was 5.8 % and 6.0 % for HAdV-F. The prevalence of HAdV was significantly higher among case-patients < 5 years of age compared with case-patients ≥ 5 years of age (pan-HAdV: 6.6 % vs. 2.0 %, p < 0.0001; HAdV-F: 8.7 % vs. 2.3 %, p = 0.04). Prevalence was significantly higher in high mortality developing countries and lowest in developed countries (pan-HAdV: 9.4 % vs. 4.0 %, p < 0.0001; HAdV-F: 11.6 % vs. 3.2 %, p = 0.0003). Understanding the burden of HAdV-associated AGE may be useful for targeted interventions, including future vaccine development.
人腺病毒（HAdV），尤其是F种人腺病毒（HAdV-F）被公认为是全球急性胃肠炎（AGE）的病因。为评估HAdV在各年龄段AGE病例中的全球流行情况，我们对2015 - 2022年期间以英文发表的研究进行了系统文献检索。我们使用广义线性混合模型生成合并患病率估计值。利用147篇纳入文章的数据，任何种类HAdV（泛HAdV）在AGE病例中的总体合并患病率为5.8%，HAdV-F为6.0%。与≥5岁的病例相比，<5岁的病例中HAdV的患病率显著更高（泛HAdV：6.6%对2.0%，p<0.0001；HAdV-F：8.7%对2.3%，p = 0.04）。高死亡率发展中国家的患病率显著更高，而发达国家最低（泛HAdV：9.4%对4.0%，p<0.0001；HAdV-F：11.6%对3.2%，p = 0.0003）。了解HAdV相关AGE的负担可能有助于进行有针对性的干预，包括未来的疫苗开发。
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