Wikswo Mary E, Kambhampati Anita K, Mattison Claire P, Chhabra Preeti, Olojo Oluwatosin, Rana Taha, Vinjé Jan, Kirkwood Carl D, Parashar Umesh D, Mirza Sara A
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA.
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA; Cherokee Nation Operational Solutions, 2 W. 2nd St., Suite 1500, Tulsa, OK 74103, USA.
J Infect Public Health. 2025 Jul;18(7):102800. doi: 10.1016/j.jiph.2025.102800. Epub 2025 May 2.
Human adenovirus (HAdV), especially HAdV species F (HAdV-F) is recognized as a cause of acute gastroenteritis (AGE) worldwide. To assess the global prevalence of HAdV in case-patients of all ages with AGE, we conducted a systematic literature search for studies published in English during 2015-2022. We generated pooled prevalence estimates using generalized linear mixed models. Using data from 147 included articles, the overall pooled prevalence among AGE case-patients of any species of HAdV (pan-HAdV) was 5.8 % and 6.0 % for HAdV-F. The prevalence of HAdV was significantly higher among case-patients < 5 years of age compared with case-patients ≥ 5 years of age (pan-HAdV: 6.6 % vs. 2.0 %, p < 0.0001; HAdV-F: 8.7 % vs. 2.3 %, p = 0.04). Prevalence was significantly higher in high mortality developing countries and lowest in developed countries (pan-HAdV: 9.4 % vs. 4.0 %, p < 0.0001; HAdV-F: 11.6 % vs. 3.2 %, p = 0.0003). Understanding the burden of HAdV-associated AGE may be useful for targeted interventions, including future vaccine development.
人腺病毒（HAdV），尤其是F种人腺病毒（HAdV-F）被公认为是全球急性胃肠炎（AGE）的病因。为评估HAdV在各年龄段AGE病例中的全球流行情况，我们对2015 - 2022年期间以英文发表的研究进行了系统文献检索。我们使用广义线性混合模型生成合并患病率估计值。利用147篇纳入文章的数据，任何种类HAdV（泛HAdV）在AGE病例中的总体合并患病率为5.8%，HAdV-F为6.0%。与≥5岁的病例相比，<5岁的病例中HAdV的患病率显著更高（泛HAdV：6.6%对2.0%，p<0.0001；HAdV-F：8.7%对2.3%，p = 0.04）。高死亡率发展中国家的患病率显著更高，而发达国家最低（泛HAdV：9.4%对4.0%，p<0.0001；HAdV-F：11.6%对3.2%，p = 0.0003）。了解HAdV相关AGE的负担可能有助于进行有针对性的干预，包括未来的疫苗开发。
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