Kc Ojbindra, Ellithi Moataz, Herdman Emily, Westmark Danielle, Wildes Tanya M, Peters Edward S, Bills Sara E, Alonso Windy, Bhatt Vijaya R
Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Division of Oncology and Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
J Cancer Surviv. 2025 May 7. doi: 10.1007/s11764-025-01822-4.
Adults living with and beyond cancer (survivors) often face physical and psychological challenges, including pain, fatigue, sleep disturbances, and depression, which impair quality of life (QOL). While exercise interventions are demonstrated to benefit survivors of solid tumors, their impact on survivors of blood cancer remains underexplored. This review evaluates the evidence regarding exercise interventions in survivors of blood cancer, focusing on intervention types, study participant characteristics, and reported outcomes.
A literature search was conducted using Embase (Elsevier), Medline (EBSCO), CINAHL (EBSCO), and Scopus (Elsevier) to identify studies on exercise interventions in survivors of blood cancer published through March 15, 2024. Articles were screened based on inclusion criteria, including adults aged 18 or older who completed cancer treatment and underwent exercise interventions. Exclusion criteria included pediatric populations, active cancer treatment, study protocols, incomplete results, or non-English publications.
Seventeen studies were identified, including nine feasibility studies and eight randomized controlled trials. Participants, predominantly white, had a median age range of 31.5-63.5 years. Interventions, often combining aerobic and resistance exercises, were delivered three times weekly over 8-12 weeks. Feasibility studies reported adherence rates of 66-87% and retention rates of 70-95%, with improvements in QOL and physical function. Randomized controlled trials similarly demonstrated benefits in fatigue, QOL, and physical function. CONCLUSIONS: Exercise interventions improve QOL for survivors of blood cancer, though long-term effectiveness and adherence require further study.
Future research should focus on diverse populations and long-term outcomes to develop tailored, accessible exercise interventions for survivors of blood cancer.
成年癌症患者及其康复后（幸存者）常面临身体和心理挑战，包括疼痛、疲劳、睡眠障碍和抑郁，这些都会损害生活质量（QOL）。虽然运动干预已被证明对实体瘤幸存者有益，但其对血癌幸存者的影响仍未得到充分研究。本综述评估了关于血癌幸存者运动干预的证据，重点关注干预类型、研究参与者特征和报告的结果。
使用Embase（爱思唯尔）、Medline（EBSCO）、CINAHL（EBSCO）和Scopus（爱思唯尔）进行文献检索，以确定截至2024年3月15日发表的关于血癌幸存者运动干预的研究。根据纳入标准筛选文章，包括年龄在18岁及以上、完成癌症治疗并接受运动干预的成年人。排除标准包括儿科人群、正在进行的癌症治疗、研究方案、不完整的结果或非英文出版物。
共确定了17项研究，包括9项可行性研究和8项随机对照试验。参与者以白人为主，中位年龄范围为31.5 - 63.5岁。干预措施通常结合有氧运动和抗阻运动，每周进行3次，持续8 - 12周。可行性研究报告的依从率为66% - 87%，保留率为70% - 95%，生活质量和身体功能得到改善。随机对照试验同样显示在疲劳、生活质量和身体功能方面有好处。
运动干预可改善血癌幸存者的生活质量，不过长期有效性和依从性仍需进一步研究。
未来的研究应关注不同人群和长期结果，为血癌幸存者制定量身定制、易于获得的运动干预措施。
