Zloto Ofira, Bakon Mati, Huna-Baron Ruth
Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel.
Neuro-Ophthalmology Unit, Tel Hashomer, Israel.
BMC Ophthalmol. 2025 May 7;25(1):280. doi: 10.1186/s12886-025-03935-x.
To examine the clinical characteristics and prognosis of occipital tumors that mimic Pseudotumor cerebri (PTC) at presentation due to venous flow obstruction compared to occipital tumors that do not cause venous flow obstruction.
The medical records of all patients who presented with increased intracranial pressure symptoms and occipital tumors were retrospectively reviewed. The control group included, an age matched group of patients with occipital tumor who presented due to homonymous visual disturbances, visual hallucinations or incidental homonymous visual field defect but without symptoms of increased intracranial pressure at presentation. Data regarding demographics, ocular presenting symptoms and signs, neurological sings, diagnosis, treatment and prognosis were collected.
At the end of follow up, None of the study group patients, with the exception of one who developed optic disc atrophy and visual deterioration, had visual complaints at the end of follow-up. In the control group, 3 patients had deterioration in the visual field at the end of follow up. Two patients, from the study group, died while in the control group, all patients were alive at the end of follow- up.
Patients with occipital tumors may present with symptoms similar to PTC secondary to venous drainage obstruction. Therefore, it is important in patients with PTC symptoms and occipital tumor to preform Magnetic-Resonance-Venography or Computed-Tomography-Venography as well. Most of the patients needed surgical intervention in addition to medical treatment in order to preserve visual functions. Probably the early treatment to this group brought to good visual prognosis that was not different from the group without venous drainage obstruction. Therefore, early diagnosis and prompt multi-disciplinary treatment may lead to better results in cases of occipital tumors with venous drainage obstruction.
研究因静脉血流受阻而在表现上类似假性脑瘤（PTC）的枕叶肿瘤与无静脉血流受阻的枕叶肿瘤的临床特征和预后。
回顾性分析所有出现颅内压升高症状和枕叶肿瘤患者的病历。对照组包括年龄匹配的因同侧视觉障碍、视幻觉或偶然的同侧视野缺损而就诊但就诊时无颅内压升高症状的枕叶肿瘤患者。收集有关人口统计学、眼部症状和体征、神经系统体征、诊断、治疗及预后的数据。
随访结束时，除1例出现视盘萎缩和视力恶化外，研究组患者均无视觉方面的主诉。对照组有3例患者在随访结束时视野恶化。研究组有2例患者死亡，而对照组所有患者在随访结束时均存活。
枕叶肿瘤患者可能因静脉引流受阻而出现类似PTC的症状。因此，对于有PTC症状和枕叶肿瘤的患者，进行磁共振静脉造影或计算机断层静脉造影也很重要。大多数患者除药物治疗外还需要手术干预以保留视觉功能。可能对该组患者的早期治疗带来了良好的视觉预后，这与无静脉引流受阻的组并无差异。因此，早期诊断和及时的多学科治疗可能会使伴有静脉引流受阻的枕叶肿瘤患者取得更好的治疗效果。
