一名肾移植受者因结核分枝杆菌和耻垢分枝杆菌感染导致粟粒性肺结核，并伴有侵袭性曲霉病。

Miliary Tuberculosis due to Mycobacterium tuberculosis and Mycobacterium smegmatis associated with invasive aspergillosis in a renal transplant recipient.

作者信息

Jorge Andrade Sierra, Mauricio Carvallo-Venegas, de Jesús Andrade-Ortega Antonio, Jorge Andrade-Ortega, José Ignacio Cerrillos-Gutiérrez, Laura Elizabeth Aguilar-Fletes, Andres Alejandro Briseño-Hernández, Aldo Carrasco-Carrizosa

机构信息

Department of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Mexico.

Department of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.

出版信息

BMC Nephrol. 2025 May 7;26(1):229. doi: 10.1186/s12882-025-04159-3.

DOI:10.1186/s12882-025-04159-3

PMID:40336084

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12060431/

Abstract

Infections in renal transplant recipients (RTRs) carry great risk of morbidity-mortality, and the risk of graft loss. Concomitant infections, although common in immunosuppressed patients, should be highly suspected. The present case involves a RTR with opportunistic pulmonary co-infections caused by Mycobacterium tuberculosis (MTb), Mycobacterium smegmatis (MSm), and Aspergillus spp. While MSm can be a colonizing microorganism, we demonstrate that it can also be pathogenic.

摘要

肾移植受者（RTR）发生感染会带来很高的发病和死亡风险，以及移植肾丢失风险。合并感染在免疫抑制患者中虽很常见，但仍应高度怀疑。本病例涉及一名RTR，其发生了由结核分枝杆菌（MTb）、耻垢分枝杆菌（MSm）和曲霉属引起的机会性肺部合并感染。虽然MSm可能是一种定植微生物，但我们证明它也可能具有致病性。