Chaichan Wasuchon, Chuamanochan Mati, Mahanupab Pongsak, Chiewchanvit Siri, Tovanabutra Napatra
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intavarorot Road, Sriphum District, Maung, Chiang Mai, 50200, Thailand.
Department of Pathology, Faculty of Medicine, Chiang Mai University, 110 Inravarorot Road, Sriphum District, Maung, Chiang Mai, 50200, Thailand.
J Med Case Rep. 2025 May 7;19(1):213. doi: 10.1186/s13256-025-05254-7.
Chilblains have emerged as a cutaneous manifestation following coronavirus disease 2019 vaccination. While there are many case reports on chilblain-like lesions, documentation from tropical countries remains limited. In this context, we report a case detailing chilblain-like lesions associated with coronavirus disease 2019 vaccination in Thailand.
A 35-year-old Thai female patient presented with several painful, red papules on the fingers and toes 9 days after receiving the mRNA-1273 vaccination. Skin biopsy was performed, and the results were consistent with chilblains. Laboratory workup revealed positive result for lupus anticoagulant. The rash completely resolved without any treatment but reappeared following the second vaccine dose.
Chilblain-like lesion following coronavirus disease 2019 vaccination is frequently observed in temperate countries, with few reports from tropical areas. The presence of lupus anticoagulant may contribute to the development of chilblains after coronavirus disease 2019 vaccination.
冻疮已成为2019冠状病毒病疫苗接种后的一种皮肤表现。虽然有许多关于冻疮样病变的病例报告，但来自热带国家的文献资料仍然有限。在此背景下，我们报告一例在泰国发生的与2019冠状病毒病疫苗接种相关的冻疮样病变的详细病例。
一名35岁的泰国女性患者在接种mRNA-1273疫苗9天后，手指和脚趾出现了几个疼痛的红色丘疹。进行了皮肤活检，结果与冻疮一致。实验室检查显示狼疮抗凝物呈阳性。皮疹未经任何治疗完全消退，但在第二次接种疫苗后再次出现。
2019冠状病毒病疫苗接种后出现的冻疮样病变在温带国家经常观察到，热带地区的报告较少。狼疮抗凝物的存在可能促使2019冠状病毒病疫苗接种后发生冻疮。
