膳食抗氧化能力指数与成年人 LDL 氧化呈负相关。
Dietary Antioxidant Capacity Indices are Negatively Correlated to LDL-Oxidation in Adults.
机构信息
Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran.
Students' Research Committee, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Int J Clin Pract. 2023 Mar 13;2023:5446163. doi: 10.1155/2023/5446163. eCollection 2023.
INTRODUCTION
Former research studies have demonstrated controversial associations between dietary indices and oxidative stress biomarkers including oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA). So, in this cross-sectional study, we aimed to assess the association of dietary total antioxidant capacity (DTAC), oxidative balance score, and phytochemical index (PI) with ox-LDL/MDA in a healthy adult population of Shiraz, Iran.
METHODS
236 individuals participated in this cross-sectional study. DTAC, OBS, and PI were calculated using a 168-item food frequency questionnaire (FFQ), which was previously validated in Iran. We measured ox-LDL and MDA in blood samples of the participants using commercially existing kits. Crude and adjusted models of linear regression were used to evaluate the relation of dietary indices with ox-LDL and MDA.
RESULTS
There was a significant association between ox-LDL and DTAC in both crude ( = -1.55; 95% CI: -2.53, -0.58; -trend = 0.002) and adjusted ( = -1.65 95% CI: -2.66, -0.64; -trend = 0.001) models. Also, a negative association was observed between ox-LDL and PI in the crude ( = -1.26 95% CI: -2.33, -0.29; -trend = 0.01) and adjusted ( = -1.36 95% CI: -2.38, -0.34; -trend = 0.01) models.
CONCLUSION
Results of this study showed that DTAC and PI were inversely associated with ox-LDL as markers of lipid peroxidation. But no correlations were seen between MDA and dietary antioxidant indices.
简介
先前的研究表明，饮食指数与氧化应激生物标志物（包括氧化型低密度脂蛋白（ox-LDL）和丙二醛（MDA））之间存在有争议的关联。因此，在这项横断面研究中，我们旨在评估伊朗设拉子健康成年人群中膳食总抗氧化能力（DTAC）、氧化平衡评分和植物化学指数（PI）与 ox-LDL/MDA 的相关性。
方法
共有 236 人参与了这项横断面研究。使用先前在伊朗验证过的 168 项食物频率问卷（FFQ）计算 DTAC、OBS 和 PI。我们使用市售试剂盒测量参与者血液样本中的 ox-LDL 和 MDA。使用线性回归的未调整和调整模型来评估饮食指数与 ox-LDL 和 MDA 的关系。
结果
在未调整（ = -1.55；95%CI：-2.53，-0.58；-trend = 0.002）和调整（ = -1.65 95%CI：-2.66，-0.64；-trend = 0.001）模型中，ox-LDL 与 DTAC 之间均存在显著相关性。此外，在未调整（ = -1.26 95%CI：-2.33，-0.29；-trend = 0.01）和调整（ = -1.36 95%CI：-2.38，-0.34；-trend = 0.01）模型中，ox-LDL 与 PI 之间也存在负相关。
结论
本研究结果表明，DTAC 和 PI 与脂质过氧化标志物 ox-LDL 呈负相关。但 MDA 与饮食抗氧化指数之间未见相关性。
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