Ion Radu T, Serbanoiu Alexandru, Salcianu Alecsandra Iulia, Popa Maria Narcisa, Filipoiu Florin Mihail, Bratu Ana M
Doctoral School of Medicine, University of Medicine and Pharmacy "Carol Davila" Bucharest, Bucharest, ROU.
Department of Radiology, Colțea Clinical Hospital, Bucharest, ROU.
Cureus. 2025 May 7;17(5):e83663. doi: 10.7759/cureus.83663. eCollection 2025 May.
Background and objectives Prostate cancer is one of the most commonly diagnosed cancers, often presenting with mild or no symptoms unless it is locally advanced or has metastasized. Given the increasing incidence of prostate cancer and its potential for severe progression, developing strategies for early detection and effective management is crucial to reduce its impact on both the population and the healthcare system. Established diagnostic methods for prostate cancer include prostate-specific antigen testing, digital rectal examination, ultrasound-guided biopsy, and histological analysis. MRI plays a key role in localizing prostate cancer, assessing its extent, and predicting tumor aggressiveness. Both multiparametric MRI and biparametric MRI (bpMRI) are currently in use. This study aims to evaluate the role and accuracy of bpMRI in patients with prostate cancer, particularly for diagnosing clinically significant cancer, assessing its extent, and monitoring patients post-treatment for early recurrence. Materials and methods This retrospective study analyzed data from 50 patients who underwent MRI examinations. The prostate lesions identified in these patients were later pathologically confirmed as prostate cancer through biopsy or surgical resection. The study aimed to evaluate the accuracy of T2-weighted imaging (T2WI), diffusion-weighted imaging, apparent diffusion coefficient (ADC) maps, and T1-weighted imaging (T1WI). Results On T2WI, the lesions appeared hypointense in 46 (92%) of the 50 cases. Diffusion restriction was observed on DWI and ADC map sequences in 43 (86%) of the cases. On T1WI, cancerous lesions were isointense in 47 (94%) cases and moderately hyperintense in three (6%) cases, particularly in lesions larger than 8 mm in diameter. Conclusions The findings of this study confirm the high accuracy of T2WI in diagnosing malignant prostate lesions. The MRI information obtained is crucial for treatment planning and for assessing patient prognosis.
前列腺癌是最常被诊断出的癌症之一，通常没有症状或症状轻微，除非处于局部晚期或已发生转移。鉴于前列腺癌发病率不断上升及其严重进展的可能性，制定早期检测和有效管理策略对于减轻其对人群和医疗系统的影响至关重要。前列腺癌的既定诊断方法包括前列腺特异性抗原检测、直肠指检、超声引导下活检和组织学分析。MRI在前列腺癌的定位、评估范围和预测肿瘤侵袭性方面起着关键作用。目前多参数MRI和双参数MRI（bpMRI）均在使用。本研究旨在评估bpMRI在前列腺癌患者中的作用和准确性，特别是用于诊断临床意义重大的癌症、评估其范围以及监测治疗后患者的早期复发情况。
这项回顾性研究分析了50例接受MRI检查患者的数据。这些患者中发现的前列腺病变后来通过活检或手术切除病理确诊为前列腺癌。该研究旨在评估T2加权成像（T2WI）、扩散加权成像、表观扩散系数（ADC）图和T1加权成像（T1WI）的准确性。
在T2WI上，50例中有46例（92%）病变呈低信号。43例（86%）在DWI和ADC图序列上观察到扩散受限。在T1WI上，47例（94%）癌性病变呈等信号，3例（6%）呈中度高信号，特别是直径大于8mm的病变。
本研究结果证实T2WI在诊断恶性前列腺病变方面具有很高的准确性。获得的MRI信息对于治疗规划和评估患者预后至关重要。
