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己烯雌酚二丙酸酯对体内处理的母鼠和胎鼠细胞中姐妹染色单体交换、微核、细胞毒性、非整倍体及细胞增殖的影响

Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo.

作者信息

Henderson L, Regan T

出版信息

Mutat Res. 1985 Sep;144(1):27-31. doi: 10.1016/0165-7992(85)90120-4.

DOI:10.1016/0165-7992(85)90120-4
PMID:4033672
Abstract

The effect of diethylstilboestrol-dipropionate on the frequency of SCEs and micronuclei, cytotoxicity, aneuploidy and cell proliferation rates of foetal liver and maternal bone marrow cells following exposure of pregnant mice was measured. An increase in the number of aneuploid and polyploid cells was observed in both tissues. There was no effect on micronuclei frequency, SCE frequency, or cell proliferation rate.

摘要

测定了己烯雌酚二丙酸酯对怀孕小鼠暴露后胎肝和母鼠骨髓细胞的姐妹染色单体交换（SCE）频率、微核、细胞毒性、非整倍体及细胞增殖率的影响。在这两种组织中均观察到非整倍体细胞和多倍体细胞数量增加。对微核频率、SCE频率或细胞增殖率没有影响。

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1
Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo.己烯雌酚二丙酸酯对体内处理的母鼠和胎鼠细胞中姐妹染色单体交换、微核、细胞毒性、非整倍体及细胞增殖的影响
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[Chromosome aberrations and sister chromatid exchanges in a human lymphocyte culture exposed to diethylstilbestrol dipropionate].[暴露于己烯雌酚二丙酸酯的人淋巴细胞培养物中的染色体畸变和姐妹染色单体交换]
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