Oduwole O, Ding C, Bitar N, Nair D, Salter S, Silverman M, Allen R, Ng Fat L, Tsochatzis E, Bell S, Mehta G, Britton A
Institute for Liver and Digestive Health, University College London, London, UK.
Department of Clinical Biochemistry, Royal Free Hospital, London, UK.
NPJ Gut Liver. 2025;2(1):10. doi: 10.1038/s44355-025-00024-0. Epub 2025 May 5.
Steatotic liver disease (SLD) prevalence in adults is estimated at 30%, but older populations are understudied. Here, SLD prevalence and associated risk factors were assessed 1,021 Whitehall II study participants (mean age 72.5) using transient elastography (FibroScan). SLD was present in 33.3% (CAP ≥ 275 dB/m), with most classified as metabolic dysfunction-associated SLD. Only 2.4% had significant fibrosis ( ≥ 7.9 kPa). Adjusted for age and sex, SLD was associated with low physical activity (OR 1.60, 95% CI 1.13-2.27), poorer motor function (SF-36 PCS OR 1.21, 95% CI 1.05-1.40), difficulties in activities of daily living (OR 3.19, 95% CI 1.17-8.64), and multimorbidity (OR 1.45, 95% CI 1.22-1.73). These associations persisted after adjustment for socioeconomic, behavioural, and cardiometabolic risk factors. Frailty was associated with SLD at higher CAP thresholds ( ≥ 290 dB/m). In this older adult sample, SLD is common and appears more as a marker of multimorbidity and low physical activity than significant fibrosis.
成人脂肪性肝病（SLD）的患病率估计为30%，但对老年人群的研究不足。在此，我们使用瞬时弹性成像（FibroScan）对1021名白厅II研究参与者（平均年龄72.5岁）的SLD患病率及相关危险因素进行了评估。33.3%的人存在SLD（CAP≥275dB/m），大多数被归类为代谢功能障碍相关的SLD。只有2.4%的人有显著纤维化（≥7.9kPa）。在对年龄和性别进行调整后，SLD与低体力活动（比值比1.60，95%置信区间1.13 - 2.27）、较差的运动功能（SF - 36身体功能评分比值比1.21，95%置信区间1.05 - 1.40）、日常生活活动困难（比值比3.19，95%置信区间1.17 - 8.64）以及多种疾病并存（比值比1.45，95%置信区间1.22 - 1.73）相关。在对社会经济、行为和心脏代谢危险因素进行调整后，这些关联依然存在。在较高的CAP阈值（≥290dB/m）下，衰弱与SLD相关。在这个老年成人样本中，SLD很常见，并且似乎更多地是多种疾病并存和低体力活动的一个标志，而非显著纤维化的标志。
