Huang Yueping, Zhang Rui, Yao Qin, Liu Jinyi, OuYang Xiali, Hui Xin, Wang Hao, He Rui, Zhao Baixiao
School of Acupuncture-Moxibustion and Tuina.
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Medicine (Baltimore). 2020 May 22;99(21):e20150. doi: 10.1097/MD.0000000000020150.
Chemotherapy-induced nausea and vomiting (CINV) make many patients have negative adherence of treatment. Acupuncture has been widely applied in treatment of CINV, but its efficacy has not been evaluated scientifically and systematically in recent years. Hence, evaluating the safety and effectiveness of acupuncture treatment in patients with CINV is the main purpose of this review.
We will search the following electronic databases from inception to Mar 2020: the Cochrane Central Register of Controlled Trials, EMBASE, PubMed, the Web of Science, China National Knowledge Infrastructure (CNKI), Traditional Chinese Medicine, Chinese Biomedical Literature Database (CBM), Wan-Fang Database and Chinese Scientific Journal Database (VIP database). All published academic data about clinical randomized controlled trials in English or Chinese related to acupuncture for treating CINV will be obtained. The primary outcomes are defined as frequency and severity of CINV during chemotherapy. The secondary outcomes are defined as any adverse events and quality of life of CINV during chemotherapy. The study selection, data extraction, and assessment of study quality will be conducted by 2 researchers independently. Review Manager Software (RevMan) V.5.3 will be performed for meta-analysis.
The results of this review will provide a high-quality synthesis of current available evidence to evaluate acupuncture is an effective and safe treatment for CINV.
The conclusion of this review will provide the highest level of evidence to judge whether acupuncture is an effective and safe treatment for patients suffered from CINV.
CRD42020153993.
化疗引起的恶心和呕吐（CINV）使许多患者对治疗产生消极依从性。针灸已广泛应用于CINV的治疗，但近年来其疗效尚未得到科学系统的评估。因此，评估针灸治疗CINV患者的安全性和有效性是本综述的主要目的。
我们将检索以下电子数据库，检索时间从建库至2020年3月：Cochrane对照试验中心注册库、EMBASE、PubMed、科学引文索引、中国知网、中国生物医学文献数据库、万方数据库和维普资讯网。将获取所有已发表的关于针灸治疗CINV的英文或中文临床随机对照试验的学术数据。主要结局定义为化疗期间CINV的发生频率和严重程度。次要结局定义为化疗期间CINV的任何不良事件和生活质量。研究的筛选、数据提取和质量评估将由两名研究人员独立进行。将使用Review Manager软件（RevMan）V.5.3进行荟萃分析。
本综述的结果将提供高质量的现有证据综合，以评估针灸是治疗CINV的一种有效且安全的疗法。
本综述的结论将提供最高级别的证据，以判断针灸对CINV患者是否为有效且安全的治疗方法。
CRD42020153993。
