Pala Barbara, Nardoianni Giulia, Gualtieri Paola, Frank Giulia, Perrone Marco Alfonso, Di Renzo Laura, Tocci Giuliano
Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome Sapienza, Sant'Andrea Hospital 1035/1039, 00189 Rome, Italy.
PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Nutrients. 2025 Mar 11;17(6):985. doi: 10.3390/nu17060985.
: Hypertension is a prevalent condition, impacting a significant amount of general population and contributing prominently to global mortality. Increasing attention has been directed towards phytotherapy products as potential complementary or alternative therapies for hypertension prevention and treatment. Among these, (NS) has shown encouraging effects in improving cardiovascular parameters. This study aimed to evaluate the efficacy of NS supplementation in reducing seated office systolic blood pressure (BP) in postmenopausal women. We also explored the dose-dependent effects of this intervention on BP levels and metabolic parameters. : We conducted an observational pilot study including 52 women, who were stratified into two active groups ( = 32) receiving two different dosages of NS ( = 16, age 54.2 ± 2.3 at 400 mg/day and = 16, age 52.3 ± 2.4 at 800 mg/day) and a control group ( = 20, age 53.9 ± 3.0). Participants were evaluated at baseline (T0), at 4 (T1) and 8 weeks (T2) for office brachial and central BP, heart rate (HR), lipid profile, body weight, and menopausal symptoms. : NS supplementation significantly reduced office systolic and diastolic BP in a dose-dependent manner ( < 0.01), with more pronounced reductions at 800 mg/day. Improvements in climacteric symptoms and reduced HR were observed as early as T1, while metabolic parameters, including lipid profile and weight, showed significant changes at T2. Notably, the 800 mg/day dosage group also experienced significant reductions in weight and body mass index. Younger age, more recent menopausal transition, and elevated baseline HR were identified as predictors of a better response to treatment. : NS supplementation demonstrates significant dose-dependent benefits in reducing office BP and improving metabolic parameters. These findings support the role of NS as an effective complementary therapy in hypertension management in postmenopausal women.
高血压是一种普遍存在的病症，影响着大量普通人群，并在全球死亡率中占据显著比例。人们越来越关注植物疗法产品，将其作为预防和治疗高血压的潜在补充或替代疗法。其中，（NS）在改善心血管参数方面显示出令人鼓舞的效果。本研究旨在评估补充NS对降低绝经后女性坐位办公室收缩压（BP）的疗效。我们还探讨了这种干预对BP水平和代谢参数的剂量依赖性影响。：我们进行了一项观察性试点研究，纳入了52名女性，她们被分为两个活性组（= 32），分别接受两种不同剂量的NS（= 16，400毫克/天，年龄54.2±2.3岁；= 16，800毫克/天，年龄52.3±2.4岁）和一个对照组（= 20，年龄53.9±3.0岁）。在基线（T0）、4周（T1）和8周（T2）时对参与者进行评估，测量办公室肱动脉和中心BP、心率（HR）、血脂谱、体重和更年期症状。：补充NS以剂量依赖性方式显著降低办公室收缩压和舒张压（<0.01），800毫克/天的降低更为明显。早在T1时就观察到更年期症状改善和HR降低，而包括血脂谱和体重在内的代谢参数在T2时出现显著变化。值得注意的是，800毫克/天剂量组的体重和体重指数也显著降低。年龄较小、绝经过渡期较近和基线HR升高被确定为对治疗反应更好的预测因素。：补充NS在降低办公室BP和改善代谢参数方面显示出显著的剂量依赖性益处。这些发现支持NS作为绝经后女性高血压管理中一种有效补充疗法的作用。
