Latiff Latiffah Abdul, Parhizkar Saadat, Dollah Mohammad Aziz, Hassan Syed Tajuddin Syed
Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia.
Medicinal Plants Research Centre, Yasuj University of Medical Sciences, Yasuj, Iran.
Iran J Basic Med Sci. 2014 Dec;17(12):980-5.
The aim of this open label crossover study was to investigate the effects of Nigella sativa on reproductive health and metabolic profile of perimenopausal women in Rawang, Malaysia.
Sixty nine perimenopausal women aged 45 to 65 were allocated into the experimental group treated orally with 1600mg/day of encapsulated pure powdered N. sativa compared to control groups treated with placebo for 12 weeks. At the end of study, participants underwent washout period for fourteen days before being crossed over and continued for another cycle of treatment. Participants were abstained from taking any other drugs, herbal preparations or food supplements throughout the study. Body weight, height, waist circumference, blood pressure, biochemical parameters and hormonal levels were measured at baseline and at the end of experiment for both cycles. Face to face interview was carried out at baseline and every week to check for compliance, minimize dropouts and to record reproductive health and quality of life indicators using Greene climacteric and SF-36 instruments.
The treatment groups in both cycles showed significant improvement with reference to low density lipoprotein cholesterol and blood glucose (P<0.05). There were no significant differences between groups in total cholesterol, high density lipoprotein and triglyceride concentration. Treatment with N. sativa induced a significant reduction of prevalence and severity of menopausal symptomsas well as significant improvement in some components of quality of life (P<0.05).
These results suggested that treatment with N. sativa exert a therapeutic and protective effect by modifying weight gain, improving lipid profile and blood glucose as well as hormonal level which is believed to play an important role in the pathogenesis of metabolic syndrome during menopause.
这项开放标签交叉研究的目的是调查黑种草对马来西亚拉旺围绝经期妇女生殖健康和代谢状况的影响。
69名年龄在45至65岁之间的围绝经期妇女被分为实验组，口服1600毫克/天的纯黑种草胶囊粉，对照组则服用安慰剂，为期12周。研究结束时，参与者经过14天的洗脱期，然后进行交叉，继续另一个治疗周期。在整个研究过程中，参与者被禁止服用任何其他药物、草药制剂或食品补充剂。在两个周期的基线和实验结束时测量体重、身高、腰围、血压、生化参数和激素水平。在基线和每周进行面对面访谈，以检查依从性，尽量减少退出，并使用格林更年期量表和SF-36工具记录生殖健康和生活质量指标。
两个周期的治疗组在低密度脂蛋白胆固醇和血糖方面均有显著改善（P<0.05）。各组在总胆固醇、高密度脂蛋白和甘油三酯浓度方面无显著差异。黑种草治疗可显著降低更年期症状的患病率和严重程度，并显著改善生活质量的某些方面（P<0.05）。
这些结果表明，黑种草治疗通过改变体重增加、改善血脂和血糖以及激素水平发挥治疗和保护作用，这些因素被认为在更年期代谢综合征的发病机制中起重要作用。
