Xavier Rafael Gariglio Clark, Colombo Salene Angelini, Silva Brendhal Almeida, Persichini Jéssica Rabelo de Oliveira, Duarte Gabriele Silva, Campos João Victor Ferreira, Silva Rodrigo Otávio Silveira, de Azevedo Maria Isabel
Escola de Veterinária, Universidade Federal de Minas Gerais. Antônio Carlos Avenue, 6627. Belo Horizonte, MG, 31.270-901, Brazil.
Escola de Veterinária, Universidade Federal de Minas Gerais. Antônio Carlos Avenue, 6627. Belo Horizonte, MG, 31.270-901, Brazil.
Top Companion Anim Med. 2025 May-Jun;66:100979. doi: 10.1016/j.tcam.2025.100979. Epub 2025 May 6.
Sporotrichosis is a neglected zoonotic infection caused by pathogenic Sporothrix species, primarily affecting the skin and lymphatic system but occasionally leading to life-threatening systemic disease in some cases. Brazil bears the highest global burden of cat and human sporotrichosis. Transmission mainly occurs through traumatic inoculation of the fungus via cat bites, scratches, thorns, or wooden splinters. To date, nosocomial transmission of Sporothrix spp. has not been reported. This report describes two cases of healthcare-associated sporotrichosis in cats in Belo Horizonte (Minas Gerais, Brazil). Both animals (cases 1 and 2) underwent trichotomy at two different veterinary clinics, with both undergoing abdominal ultrasound examination and one (case 2) receiving further venous access. Small skin lesions caused by the trichotomy presented with purulent content approximately six days after the procedure. Samples from the cutaneous lesions were collected and subjected to cytological examination and mycological culture. S. brasiliensis was confirmed through species-specific PCR and calmodulin (CAL) gene sequencing. Phylogenetic analysis revealed that both isolates clustered with clinical S. brasiliensis isolates extracted from infected cats, dogs, and humans in Brazil. These findings highlight the potential for S. brasiliensis transmission through contaminated fur clippers in veterinary hospitals, underscoring the risk of nosocomial infection in animals.
孢子丝菌病是一种由致病性孢子丝菌属引起的被忽视的人畜共患感染病，主要影响皮肤和淋巴系统，但在某些情况下偶尔会导致危及生命的全身性疾病。巴西承担着全球最高的猫和人类孢子丝菌病负担。传播主要通过猫咬伤、抓伤、刺伤或木片等造成真菌的创伤性接种而发生。迄今为止，尚未有孢子丝菌属医院内传播的报道。本报告描述了巴西贝洛奥里藏特（米纳斯吉拉斯州）两例与医疗保健相关的猫孢子丝菌病病例。两只动物（病例1和病例2）在两家不同的兽医诊所接受了毛发修剪，均接受了腹部超声检查，其中一只（病例2）还接受了进一步的静脉通路操作。毛发修剪引起的小皮肤损伤在术后约六天出现脓性分泌物。采集了皮肤损伤部位的样本并进行了细胞学检查和真菌培养。通过种特异性PCR和钙调蛋白（CAL）基因测序确认了巴西孢子丝菌。系统发育分析表明，这两个分离株与从巴西感染的猫、狗和人类中提取的临床巴西孢子丝菌分离株聚集在一起。这些发现突出了巴西孢子丝菌通过兽医医院受污染的毛发剪传播的可能性，强调了动物医院内感染的风险。
