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利用表面增强拉曼光谱进行基于呼吸的诊断。

Harnessing Surface-Enhanced Raman Spectroscopy for Breath-Based Diagnostics.

作者信息

Lujan-Cabrera Ivan A, Morales-Narváez Eden

机构信息

Biophotonic Nanosensors Laboratory, Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Querétaro 76230, Mexico.

出版信息

Anal Chem. 2025 May 20;97(19):10099-10109. doi: 10.1021/acs.analchem.5c00167. Epub 2025 May 8.

DOI:10.1021/acs.analchem.5c00167
PMID:40340302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12096349/
Abstract

Human breath contains a myriad of analytes that are associated with human health conditions, making it a noninvasive source of biomarkers. Researchers and engineers are pushing the boundaries of breath analysis for the next generation of diagnostics. Breath analysis with surface enhanced Raman spectroscopy, which allows for the identification of molecular fingerprints in a simple way, represents a powerful platform for the next generation of sensors which are expected to provide tools for personalized healthcare and preventive medicine.

摘要

人类呼出的气体包含大量与人类健康状况相关的分析物，使其成为生物标志物的无创来源。研究人员和工程师正在拓展呼吸分析的边界，以用于下一代诊断。表面增强拉曼光谱技术进行的呼吸分析能够以简单的方式识别分子指纹，为下一代传感器提供了一个强大的平台，有望为个性化医疗保健和预防医学提供工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/469e7193510c/ac5c00167_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/247110686f57/ac5c00167_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/71d4ba929ea9/ac5c00167_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/f4a42659edf6/ac5c00167_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/469e7193510c/ac5c00167_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/247110686f57/ac5c00167_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/71d4ba929ea9/ac5c00167_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/f4a42659edf6/ac5c00167_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3c/12096349/469e7193510c/ac5c00167_0004.jpg

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PNAS Nexus. 2025 Apr 15;4(4):pgaf116. doi: 10.1093/pnasnexus/pgaf116. eCollection 2025 Apr.
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Anal Chem. 2025 Jan 14;97(1):130-139. doi: 10.1021/acs.analchem.4c03261. Epub 2024 Dec 20.
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E.Co.Tech Breathalyzer: A Pilot Study of a Non-invasive COVID-19 Diagnostic Tool for Light and Non-smokers.
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ACS Meas Sci Au. 2024 Jul 25;4(5):496-503. doi: 10.1021/acsmeasuresciau.4c00020. eCollection 2024 Oct 16.
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Yolk-Shell Hierarchical Pore Au@MOF Nanostructures: Efficient Gas Capture and Enrichment for Advanced Breath Analysis.蛋黄壳型分级孔 Au@MOF 纳米结构：高级呼吸分析用高效气体捕获与富集。
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