Shokry Mohamed Magdy Elsayed Mohamed, Melek Lydia Nabil Fouad, Amer Tasneem Ahmed
Faculty of Dentistry, Alexandria University, Champlion Street, El-Azarita, Alexandria, Egypt.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Champlion Street, El-Azarita, Alexandria, Egypt.
BMC Oral Health. 2025 May 8;25(1):693. doi: 10.1186/s12903-025-06027-w.
The presence of an osseous cavity after cyst enucleation is a clinical challenge that needs to be considered. Using pure autologous concentrations of platelets, platelet-rich fibrin (PRF), as a graft material after cyst removal has shown promising effects. However, PRF has limitations in terms of durability, as it usually resorbs within 10-14 days, thus Mourão et al. introduced a new technique for PRF preparation to obtain an albumin gel-platelet-rich fibrin mixture (Alb-PRF), a new autologous material, that can remain stable for 4-6 months with the ability to regenerate bone. This research aimed to evaluate the effect of Alb-PRF on bone regeneration after jaw cyst enucleation via 3-dimensional (3D) volumetric analysis.
Twenty participants, with jaw cysts, were split into two groups. The Alb-PRF group included 10 individuals treated by enucleation and Alb-PRF application, and the control group included 10 individuals treated conventionally by enucleation without any additives. Cone beam computed tomography (CBCT) was conducted immediately following surgery (T1) and six months later (T2) to measure the volume of the residual bone cavity and the mean bone density of the regenerated bone using On-demand 3D viewer. Paired t test was used to compare the postoperative immediate results with the post-6-months results, whereas Student t test was used to compare the Alb-PRF group with the control group.
At the 6-month follow-up, the volume of the residual bone cavity had declined and the bone density had increased significantly in both the Alb-PRF group and the control group (P < 0.001) compared with the immediate postoperative values. Although the changes in volume and density were greater in the Alb-PRF group than in the control group, there was no a noticeable difference between the two groups. (P = 0.821) and (P = 0.533), respectively.
There was no difference in bone regeneration between Alb-PRF and conventional blood clots after jaw cyst enucleation.
The trial was retrospectively registered at the Clinicaltrial.gov registry (Registration ID #NCT05658900). It was first submitted on 12/12/2022 and first posted on 21/12/2022.
囊肿摘除术后骨腔的存在是一个需要考虑的临床挑战。使用纯自体浓缩血小板，即富血小板纤维蛋白（PRF），作为囊肿切除后的移植材料已显示出有前景的效果。然而，PRF在耐久性方面存在局限性，因为它通常在10 - 14天内吸收，因此莫朗等人引入了一种新的PRF制备技术，以获得白蛋白凝胶 - 富血小板纤维蛋白混合物（Alb - PRF），这是一种新的自体材料，能够在4 - 6个月内保持稳定并具有骨再生能力。本研究旨在通过三维（3D）体积分析评估Alb - PRF对颌骨囊肿摘除术后骨再生的影响。
20名患有颌骨囊肿的参与者被分为两组。Alb - PRF组包括10名接受囊肿摘除及Alb - PRF应用治疗的个体，对照组包括10名接受传统囊肿摘除术且未添加任何物质治疗的个体。术后立即（T1）和6个月后（T2）进行锥形束计算机断层扫描（CBCT），使用按需3D观察器测量残余骨腔的体积和再生骨的平均骨密度。配对t检验用于比较术后即刻结果与6个月后的结果，而学生t检验用于比较Alb - PRF组与对照组。
在6个月的随访中，与术后即刻值相比，Alb - PRF组和对照组的残余骨腔体积均下降，骨密度均显著增加（P < 0.001）。尽管Alb - PRF组的体积和密度变化大于对照组，但两组之间没有明显差异，分别为（P = 0.821）和（P = 0.533）。
颌骨囊肿摘除术后，Alb - PRF与传统血凝块在骨再生方面没有差异。
该试验在Clinicaltrial.gov注册中心进行了回顾性注册（注册号#NCT05658900）。它于2022年12月12日首次提交，并于2022年12月21日首次发布。
