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豚鼠眼前葡萄膜中血管活性肠肽(VIP)免疫反应性神经纤维

Vasoactive intestinal polypeptide (VIP)-immunoreactive nerve fibers in the anterior uvea of the guinea pig.

作者信息

Uusitalo H, Lehtosalo J I, Palkama A

出版信息

Ophthalmic Res. 1985;17(4):235-40. doi: 10.1159/000265378.

Abstract

The presence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity, especially in the anterior part of the guinea pig uvea, was studied using an indirect immunofluorescence technique. In the ciliary body, thin varicose VIP fibers displaying VIP immunoreactivity were observed in the ciliary muscle and in the ciliary processes. The iris was virtually free of VIP fibers. In the choroid, VIP-immunoreactive fibers were seen mainly in close association with the choroidal blood vessels. The histochemical localization of VIP-immunoreactive fibers in the anterior uvea suggests that the physiological role of neuronal VIP in the uvea is not only associated with the regulation of the blood flow of the choroid but also with the functions of ciliary muscle and ciliary epithelium.

摘要

采用间接免疫荧光技术研究了血管活性肠肽(VIP)样免疫反应性的存在情况,特别是在豚鼠葡萄膜前部。在睫状体中,在睫状肌和睫状突中观察到显示VIP免疫反应性的细的曲张VIP纤维。虹膜几乎没有VIP纤维。在脉络膜中,VIP免疫反应性纤维主要见于与脉络膜血管紧密相关处。VIP免疫反应性纤维在前部葡萄膜中的组织化学定位表明,神经元VIP在葡萄膜中的生理作用不仅与脉络膜血流的调节有关,还与睫状肌和睫状上皮的功能有关。

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