Stone R A, Tervo T, Tervo K, Tarkkanen A
Acta Ophthalmol (Copenh). 1986 Feb;64(1):12-8. doi: 10.1111/j.1755-3768.1986.tb06865.x.
Using immunohistochemical techniques, vasoactive intestinal polypeptide (VIP) is visualized in nerves distributed to the human eye. Immunoreactive nerve fibers occur about limbal blood vessels and within the trabecular meshwork. In the iris, free-running stromal nerves are the most common, but nerves to both dilator and sphincter muscles are present as well. Immunoreactive nerves are seen within the ciliary muscle and occasionally within a ciliary process. Innervation to choroidal blood vessels constitutes a prominent feature; innervation to more anterior uveal blood vessels is seen only irregularly. Immunoreactive to more anterior uveal blood vessels is seen only irregularly. Immunoreactive nerves are apposed to melanocytes throughout the uvea. The present findings extend prior reports in the human eye, indicating a potential role for VIP in ocular physiology. Additional neuroanatomical, biochemical and physiological studies are necessary to define fully the ocular function of VIP and to determine ultimely whether VIP has clinical and pharmacological implications.
利用免疫组织化学技术，在分布于人类眼睛的神经中可观察到血管活性肠肽（VIP）。免疫反应性神经纤维出现在角膜缘血管周围和小梁网内。在虹膜中，游离的基质神经最为常见，但也存在支配瞳孔开大肌和瞳孔括约肌的神经。在睫状肌内可见免疫反应性神经，偶尔在睫状突内也可见到。脉络膜血管的神经支配是一个显著特征；而眼前部葡萄膜血管的神经支配仅不规则可见。对眼前部葡萄膜血管的免疫反应性仅不规则可见。免疫反应性神经在整个葡萄膜中与黑素细胞相邻。目前的研究结果扩展了之前关于人眼的报道，表明VIP在眼生理学中具有潜在作用。需要进行更多的神经解剖学、生物化学和生理学研究，以全面界定VIP的眼功能，并最终确定VIP是否具有临床和药理学意义。
