Sugimoto Hirofumi, Ihana-Sugiyama Noriko, Sugiyama Takehiro, Kodani Noriko, Bouchi Ryotaro, Ohsugi Mitsuru, Ueki Kohjiro, Kajio Hiroshi
Department of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo, Japan.
Diabetes and Metabolism Information Center, Diabetes Research Center, National Institute of Global Health and Medicine, Japan Institute for Health Security, Shinjuku-Ku, Tokyo, Japan.
J Diabetes Investig. 2025 Aug;16(8):1543-1550. doi: 10.1111/jdi.70067. Epub 2025 May 8.
AIMS/INTRODUCTION: Investigating the causes of death in individuals with diabetes compared with those without is essential for understanding diabetes care. However, methods for identifying individuals with diabetes within populations vary. We conducted a comparison of these groups under identical conditions, analyzing differences in causes and age at death, and assessing how different identification methods influence these outcomes.
This study used the clinical records of inpatients who died at the National Center for Global Health and Medicine from September 1, 2010, to December 31, 2020. Individuals with or without diabetes were defined using prescriptions and laboratory data. The cause of death was determined by the name of the primary illness provided by the attending physician at the time of death. Individuals with diabetes were stratified by different definitions, and their age at death was compared.
In Individuals with diabetes, males accounted for 67.6%, and in those without diabetes, 57.0%. The mean age at death was 75.0 ± 11.8 and 73.8 ± 16.0 years, respectively. Malignant neoplasia was the most common cause of death in both groups, with a higher frequency in individuals with diabetes (36.9% vs 31.0%). Age at death of individuals with diabetes differed by up to 1.5 years, depending on the definitions.
Direct comparisons suggested that malignant neoplasia was the leading cause of death, and individuals with diabetes had a higher mean age at death. The method used to identify diabetes influenced these outcomes, emphasizing the importance of careful consideration in mortality studies.
目的/引言：与非糖尿病患者相比，研究糖尿病患者的死亡原因对于理解糖尿病护理至关重要。然而，在人群中识别糖尿病患者的方法各不相同。我们在相同条件下对这些群体进行了比较，分析了死亡原因和年龄的差异，并评估了不同的识别方法如何影响这些结果。
本研究使用了2010年9月1日至2020年12月31日在国立全球健康与医学中心死亡的住院患者的临床记录。根据处方和实验室数据定义有无糖尿病患者。死亡原因由主治医生在死亡时提供的主要疾病名称确定。糖尿病患者根据不同定义进行分层，并比较其死亡年龄。
糖尿病患者中男性占67.6%，非糖尿病患者中男性占57.0%。平均死亡年龄分别为75.0±11.8岁和73.8±16.0岁。恶性肿瘤是两组中最常见的死亡原因，糖尿病患者中的发生率更高（36.9%对31.0%）。根据定义，糖尿病患者的死亡年龄差异高达1.5岁。
直接比较表明，恶性肿瘤是主要死亡原因，糖尿病患者的平均死亡年龄更高。用于识别糖尿病的方法影响了这些结果，强调了在死亡率研究中仔细考虑的重要性。
