相位角是普通人群中肌肉减少症和认知障碍的一种潜在新型早期标志物。

Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population.

作者信息

Ikeue Kentaro, Kato Hisashi, Tanaka Masashi, Yamakage Hajime, Kato Sayaka, Iwasa Masayo, Oishi Kan, Yamamoto Yuiko, Kanasaki Megumi, Masuda Izuru, Ishii Kojiro, Satoh-Asahara Noriko

机构信息

Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, Japan.

Graduate School of Health and Sports Science, Doshisha University, Kyoto, Japan.

出版信息

J Cachexia Sarcopenia Muscle. 2025 Jun;16(3):e13820. doi: 10.1002/jcsm.13820.

DOI:10.1002/jcsm.13820

PMID:40341877

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12059471/

Abstract

BACKGROUND

Sarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population.

METHODS

This was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53-70] and 100 women with a median age of 58 years [interquartile range = 49-68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height, ASM/body mass index, handgrip strength (HGS), HGS/upper extremity skeletal muscle mass and phase angle (PhA). We examined the associations between these indices and cognitive function using the Japanese version of the Montreal Cognitive Assessment (MoCA-J).

RESULTS

Higher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10-0.78], p = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (β = 0.27, p = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (r = 0.22, p = 0.031), which is one of the earliest manifestations of cognitive impairment. The PhA in men was also positively correlated with memory (r = 0.24, p = 0.002).

CONCLUSIONS

PhA is a potentially novel index for detecting the risk of sarcopenia and cognitive decline in the general population.

摘要

背景

肌肉减少症与痴呆风险增加相关。本研究旨在阐明一般人群中与肌肉减少症相关指标与认知功能下降之间的关系。

方法

这是一项横断面研究，纳入了263名参与者（163名男性，中位年龄60岁[四分位间距=53 - 70]；100名女性，中位年龄58岁[四分位间距=49 - 68]），他们均接受了全面的健康检查。与肌肉减少症相关的指标包括四肢骨骼肌质量（ASM）/身高、ASM/体重指数、握力（HGS）、HGS/上肢骨骼肌质量和相位角（PhA）。我们使用日本版蒙特利尔认知评估量表（MoCA-J）来研究这些指标与认知功能之间的关联。

结果

较高的PhA作为肌肉质量的一个指标，与女性轻度认知障碍（MCI）风险较低相关（调整后的优势比=0.28[95%置信区间，0.10 - 0.78]，p = 0.014），而其他与肌肉减少症相关的指标在两性中与MCI均无显著关联。女性的PhA与MoCA-J评分呈正相关（β = 0.27，p = 0.005）。此外，女性的PhA与认知子领域呈正相关，包括记忆（r = 0.22，p = 0.031），记忆是认知障碍最早的表现之一。男性的PhA也与记忆呈正相关（r = 0.24，p = 0.002）。