Yurkow Sydney, Ivezaj Valentina, Grilo Carlos M
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Obesity (Silver Spring). 2025 Jun;33(6):1058-1066. doi: 10.1002/oby.24289. Epub 2025 May 7.
Although recent rigorous trials have demonstrated effectiveness of behaviorally based weight-loss treatment (BBWLT) for binge-eating disorder (BED) with coexisting obesity, concerns have been raised that such interventions are contraindicated because they might trigger or exacerbate eating disorder (ED) psychopathology. This secondary analysis of a BBWLT trial examined heterogeneity of outcomes to identify the frequency that individuals experienced increased symptoms.
One hundred ninety-one participants with BED and obesity in a 6-month BBWLT trial were assessed for binge eating, ED psychopathology, and weight at baseline, at posttreatment, and at a 12-month follow-up after treatment (i.e., 18 months after baseline). Changes were examined at the individual level to identify cases of any increased features.
At posttreatment, 95.3% (n = 162) of participants reported decreased binge-eating frequency, and 87.6% (n = 149) reported decreased ED psychopathology scores. At the 12-month follow-up, 97.1% (n = 135) reported decreased binge-eating frequency, and 93.0% (n = 120) reported decreased ED psychopathology scores. Inspection of the few instances of any increases revealed mostly small magnitudes.
Frequency of cases with any increased symptoms of binge eating and/or ED psychopathology was quite low at posttreatment and at 1 year after ending BBWLT for BED and obesity. These participant-level findings add important clinical context regarding overall improvements with BBWLT for BED with obesity (large effect sizes) and challenge concerns that BBWLT exacerbates ED psychopathology.
尽管最近的严格试验已证明基于行为的减肥治疗(BBWLT)对伴有肥胖症的暴饮暴食症(BED)有效,但有人担心此类干预措施是禁忌的,因为它们可能引发或加剧饮食失调(ED)的精神病理学症状。这项对BBWLT试验的二次分析检查了结果的异质性,以确定个体出现症状加重的频率。
在一项为期6个月的BBWLT试验中,对191名患有BED和肥胖症的参与者在基线、治疗后以及治疗后12个月随访(即基线后18个月)时进行暴饮暴食、ED精神病理学和体重评估。在个体层面检查变化情况,以确定任何特征增加的病例。
治疗后,95.3%(n = 162)的参与者报告暴饮暴食频率降低,87.6%(n = 149)的参与者报告ED精神病理学得分降低。在12个月随访时,97.1%(n = 135)的参与者报告暴饮暴食频率降低,93.0%(n = 120)的参与者报告ED精神病理学得分降低。对少数任何增加情况的检查显示幅度大多较小。
在针对BED和肥胖症结束BBWLT治疗后,暴饮暴食和/或ED精神病理学症状有任何增加的病例频率在治疗后和1年时相当低。这些参与者层面的发现为BBWLT对伴有肥胖症的BED的总体改善(大效应量)增添了重要的临床背景,并对BBWLT会加剧ED精神病理学的担忧提出了挑战。