Verly Eliseu, Meyer Armando, Sichieri Rosely, Rosa Ana Cristina Simoes, Faerstein Eduardo
Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Environmental and Occupational Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
J Health Pollut. 2024 Sep 18;12(1-4):017003. doi: 10.1289/JHP1033. eCollection 2024 Dec.
The current literature on associations between organochlorine pesticides and leukocyte telomere length (LTL) is conflicted, showing positive, inverse, or no association, findings that might be related to methodological issues and population characteristics, including the baseline LTL. Alternative exploration of this relationship over the whole LTL distribution may add information to help understand the role of pesticides in telomere shortening or enlargement.
We evaluated the association between environmental dichlorodiphenyldichloroethylene (DDE) exposure and percentiles of LTL in a sample of adults living in the urban area of Rio de Janeiro, Brazil.
LTL, serum pesticide concentration, and the covariates were determined cross-sectionally in a sample of 471 adults from the Pró-Saúde Study, a cohort of civil servants at a university campus in Rio de Janeiro, Brazil, conducted from July 2012 to October 2013. The percentiles (5th to 95th) of LTL (outcome variable) were modeled using quantile regression (QR) models with DDE as exposure and adjusted for age, sex, educational level, total body fat mass, total serum lipids, smoking, alcohol intake, and caloric share of and ultra-processed foods.
LTL and serum DDE were telomere to single-copy gene ratio (T/S ratio) and , respectively. Serum DDE was not detected in 44% of the samples. QR coefficients were positive and significant in the first percentiles (up to the 15th percentile) and inverse and significant at the 95th percentile. No significant association was observed between serum DDE and mean LTL ( ; ).
DDE exposure predicts some quantiles of LTL distribution, with a positive relationship in the first quantiles and inverse at the highest quantile. This study added new information to help understand the role of pesticides in telomere shortening or enlargement; however, given the few studies and the conflicting results, longitudinal investigations are needed to clarify this association. https://doi.org/10.1289/JHP1033.
目前关于有机氯农药与白细胞端粒长度（LTL）之间关联的文献存在矛盾，呈现出正相关、负相关或无关联，这些结果可能与方法学问题及人群特征有关，包括基线LTL。在整个LTL分布范围内对这种关系进行替代性探索可能会增加信息，有助于理解农药在端粒缩短或延长中的作用。
我们评估了巴西里约热内卢市区成年人群样本中环境二氯二苯二氯乙烯（DDE）暴露与LTL百分位数之间的关联。
在2012年7月至2013年10月于巴西里约热内卢大学校园开展的一项公务员队列研究——健康促进研究中，对471名成年人样本进行横断面研究，测定其LTL、血清农药浓度及协变量。以DDE作为暴露因素，采用分位数回归（QR）模型对LTL（结局变量）的百分位数（第5至95百分位数）进行建模，并对年龄、性别、教育水平、总体脂肪量、总血脂、吸烟、饮酒及未加工和超加工食品的热量占比进行校正。
LTL和血清DDE分别为端粒与单拷贝基因比值（T/S比值）和 。44%的样本中未检测到血清DDE。QR系数在最初的百分位数（直至第15百分位数）为正且具有显著性，在第95百分位数为负且具有显著性。血清DDE与平均LTL之间未观察到显著关联（ ； ）。
DDE暴露可预测LTL分布的某些分位数，在最初的分位数中呈正相关，在最高分位数中呈负相关。本研究增加了新信息，有助于理解农药在端粒缩短或延长中的作用；然而，鉴于研究较少且结果相互矛盾，需要进行纵向研究以阐明这种关联。https://doi.org/10.1289/JHP1033
