Department of Environmental Health Engineering, School of Health, Arak University of Medical Sciences, Arāk, Iran.
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Enghelab St., Tehran, Iran.
Arch Environ Contam Toxicol. 2020 Jul;79(1):122-130. doi: 10.1007/s00244-020-00732-z. Epub 2020 Apr 16.
Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) through food, water, and air occurred during the life, which may change telomere length (TL) in peripheral blood leukocytes. The present study was designed to investigate the association between TL and serum levels of PCBs and OCPs in Tehran male's population. Whole blood samples were randomly taken from 300 adult males, aged between 25 and 40 years. TL was determined by real-time PCR to measure the number of the telomere (T) repeats to the number of a single-copy gene (S). We applied the multivariate linear regression model to compare the effect of each lipid adjusted serum levels of PCBs and OCPs congener on the TL, with adjustment for age, body mass index, education, smoking, and food patterns. Each doubling of the nondioxin-like PCBs, dioxin-like PCBs, and OCPs levels were associated with 1.9% [95% confidence interval (CI) - 0.70 to 5.40%], 2.5% (95% CI 0.30-8.3%), and - 2.4% (95% CI - 0.70 to - 6.2%) variation in the TL, respectively. The percent difference in the TL with exposure to nondioxin-like PCBs, dioxin-like PCBs, and OCPs for participants with older than age 37 years were 6.45% (95% CI 2.81-16.50%), 4.52% (95% CI 1.60-10.54%), and - 7.44% (95% CI - 1.55 to - 15.51%), respectively. Exposures to nondioxin-like PCBs (except for PCB 28 and 52) with high chlorine in structure and dioxin-like PCBs were related to longer TLs. Conversely, serum levels of OCPs can be associated with oxidative stress and systemic inflammation that lead to telomere shortening.
个体在一生中通过食物、水和空气接触到多氯联苯（PCBs）和有机氯农药（OCPs），这可能会改变外周血白细胞中的端粒长度（TL）。本研究旨在调查德黑兰男性人群中 TL 与血清 PCBs 和 OCPs 水平之间的关系。从 300 名年龄在 25 岁至 40 岁之间的成年男性中随机抽取全血样本。通过实时 PCR 测定 TL，以测量端粒（T）重复数与单个拷贝基因（S）数的比值。我们应用多元线性回归模型比较了每种脂质调整后的血清 PCBs 和 OCPs 同系物水平对 TL 的影响，同时调整了年龄、体重指数、教育、吸烟和饮食模式。非二噁英类 PCBs、二噁英类 PCBs 和 OCPs 水平每增加一倍，TL 分别增加 1.9%（95%置信区间 [CI] -0.70 至 5.40%）、2.5%（95% CI 0.30 至 8.3%）和 -2.4%（95% CI -0.70 至 -6.2%）。暴露于非二噁英类 PCBs、二噁英类 PCBs 和 OCPs 的参与者中，年龄大于 37 岁的人的 TL 差异百分比分别为 6.45%（95% CI 2.81-16.50%）、4.52%（95% CI 1.60-10.54%）和 -7.44%（95% CI -1.55 至 -15.51%）。结构中含高氯的非二噁英类 PCBs（除 PCB28 和 52 外）和二噁英类 PCBs 的暴露与较长的 TL 有关。相反，OCPs 的血清水平可能与氧化应激和全身炎症有关，这会导致端粒缩短。
