Hu Xingyu, Li Yiran, Jiang Haiyun, Luo Zhihao, Zou Jihua, Zheng Xiaoyan
School of Rehabilitation Sciences, Southern Medical University, Guangzhou, China.
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Front Cardiovasc Med. 2025 Apr 24;12:1419095. doi: 10.3389/fcvm.2025.1419095. eCollection 2025.
Based on clinical observations and expert recommendations, Baduanjin exercise has demonstrated a positive impact on maintaining and enhancing cardiovascular function. Despite clinical observations of Baduanjin's cardiovascular benefits, systematic evidence for older adults remains limited. Moreover, the effects of Baduanjin exercise on functional capacity in older adults with cardiovascular diseases have not been adequately investigated. Therefore, we conducted a systematic review and meta-analysis to evaluate the overall efficacy and effectiveness of Baduanjin exercise on functional capacity and cardiovascular function in older adults with cardiovascular diseases.
We conducted a systematic review and meta-analysis, searching related trials through March 7, 2025, across six databases: PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, and China Science Journal Database (VIP). Methodological quality was assessed using the Cochrane Risk of Bias Tool, and a meta-analysis of comparative effects was performed using Review Manager v.5.3 software.
A total of 26 randomized controlled trials involving 2,080 participants were included in this meta-analysis. The results indicate that Baduanjin exercise significantly enhances functional capacity as measured by 6MWT compared to the control group (MD: 41.75, 95% CI: 33.08-50.42, < 0.00001, = 85%), and improves cardiovascular health markers including LVEF (MD: 5.04, 95% CI: 3.40-6.68, < 0.00001, = 82%). In dose-subgroup analysis, moderate exercise intensity (30-60 min per time) significantly improved cardiovascular function compared with those of the control group (MD: 56.36, 95% CI: 41.49-71.24, < 0.00001, = 92%). The secondary outcomes also demonstrated benefits in cardiac remodeling indices, including reductions LVESD (MD: -1. 67, 95% CI: -2.76 to -0.59, = 0.002, = 95%), LVDD (MD: -2.38, 95% CI: -3.59 to -1.17, = 0.0001, = 93%). In addition, Baduanjin exercise improved blood biomarkers such as NT-proBNP (MD: -183.83, 95% CI: -309.83 to -57.83, < 0.00001, = 82%) and NO (MD: 3.54, 95% CI: 1.74-5.34, = 0.0001, = 0%). What's more, it also decreased MLHFQ (MD: -7.00, 95% CI: -9.54 to -4.45, = 0.0003, = 79%).
Moderate-intensity Baduanjin (30-60 min/session) significantly improved 6MWT distance and cardiac function parameters by LVEF, LVESD, and LVDD, etc.
identifier, PROSPERO registration number: (CRD42023477008).
基于临床观察和专家建议，八段锦锻炼已证明对维持和增强心血管功能有积极影响。尽管有关于八段锦对心血管有益的临床观察，但针对老年人的系统性证据仍然有限。此外，八段锦锻炼对患有心血管疾病的老年人功能能力的影响尚未得到充分研究。因此，我们进行了一项系统评价和荟萃分析，以评估八段锦锻炼对患有心血管疾病的老年人功能能力和心血管功能的总体疗效和效果。
我们进行了一项系统评价和荟萃分析，通过2025年3月7日在六个数据库中检索相关试验：PubMed、科学网、考克兰图书馆、中国知网、万方数据和中国科学期刊数据库（维普）。使用考克兰偏倚风险工具评估方法学质量，并使用Review Manager v.5.3软件进行比较效应的荟萃分析。
本荟萃分析共纳入26项随机对照试验，涉及2080名参与者。结果表明，与对照组相比，八段锦锻炼通过6分钟步行试验（6MWT）测量显著提高了功能能力（平均差：41.75，95%置信区间：33.08 - 50.42，P < 0.00001，I² = 85%），并改善了心血管健康指标，包括左心室射血分数（LVEF）（平均差：5.04，95%置信区间：3.40 - 6.68，P < 0.00001，I² = 82%）。在剂量亚组分析中，中等运动强度（每次30 - 60分钟）与对照组相比显著改善了心血管功能（平均差：56.36，95%置信区间：41.49 - 71.24，P < 0.00001，I² = 92%）。次要结果还显示在心脏重塑指标方面有益处，包括左心室舒张末期内径（LVESD）降低（平均差：-1.67，95%置信区间：-2.76至-0.59，P = 0.002，I² = 95%），左心室舒张末期内径（LVDD）降低（平均差：-2.38，95%置信区间：-3.59至-1.17，P = 0.0001，I² = 93%）。此外，八段锦锻炼改善了血液生物标志物，如N末端脑钠肽前体（NT - proBNP）（平均差：-183.83，95%置信区间：-309.83至-57.83，P < 0.00001，I² = 82%）和一氧化氮（NO）（平均差：3.54，95%置信区间：1.74 - 5.34，P = 0.0001，I² = 0%）。更重要的是，它还降低了明尼苏达心力衰竭生活质量量表（MLHFQ）（平均差：-7.00，百分之95置信区间：-9.54至-4.45，P = 0.0003，I² = 79%）。
中等强度的八段锦（每次30 - 60分钟）通过LVEF、LVESD和LVDD等显著改善了6MWT距离和心脏功能参数。
标识符，PROSPERO注册号：（CRD42023477008）。
