Dai Xiaolin, Zheng Yu, Cui Jianrong, Zeng Yuqi, Yang Bo, Zhang Zhanlin
Department of Pharmacy, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, China.
Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, PR China.
Mater Today Bio. 2025 Apr 24;32:101804. doi: 10.1016/j.mtbio.2025.101804. eCollection 2025 Jun.
Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, progressive cartilage degradation, and bone erosion. Recent research has implicated ferroptosis not only in autoimmune hepatitis but also in the pathogenesis and progression of autoimmune disorders like RA. Consequently, numerous therapeutic strategies have begun to target the ferroptosis pathway, particularly in the design and development of nanodrug delivery systems (NDDSs). While previous reviews have comprehensively discussed the mechanisms of ferroptosis, related signaling pathways, and NDDS materials, recent studies have further elucidated the interplay between ferroptosis and various metabolic pathways, providing a robust theoretical basis for the design of NDDS-based ferroptosis strategies. This review focuses on investigating the role of ferroptosis in the development of RA, aiming to elucidate how targeting ferroptosis can offer novel therapeutic concepts and potential treatments for RA patients. Specifically, it summarizes the design strategies of ferroptosis-based NDDSs different pathways and highlights the feasibility of RA treatment regimens based on the ferroptosis mechanism. Furthermore, the review critically discusses the current limitations of NDDSs and offers perspectives on future research directions in this field.
类风湿关节炎（RA）是一种慢性炎症性疾病，其特征为关节炎症、进行性软骨降解和骨质侵蚀。最近的研究表明，铁死亡不仅与自身免疫性肝炎有关，还与RA等自身免疫性疾病的发病机制和进展有关。因此，许多治疗策略已开始针对铁死亡途径，特别是在纳米药物递送系统（NDDS）的设计和开发方面。虽然以前的综述已经全面讨论了铁死亡的机制、相关信号通路和NDDS材料，但最近的研究进一步阐明了铁死亡与各种代谢途径之间的相互作用，为基于NDDS的铁死亡策略的设计提供了坚实的理论基础。本综述重点研究铁死亡在RA发展中的作用，旨在阐明靶向铁死亡如何为RA患者提供新的治疗理念和潜在治疗方法。具体而言，它总结了基于铁死亡的NDDS的不同设计策略，并强调了基于铁死亡机制的RA治疗方案的可行性。此外，本综述批判性地讨论了NDDS目前的局限性，并对该领域未来的研究方向提出了展望。
