Key Laboratory of Smart Drug Delivery(Ministry of Education), State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy Fudan University, Shanghai 201203, People's Republic of China.
Key Laboratory of Smart Drug Delivery(Ministry of Education), State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy Fudan University, Shanghai 201203, People's Republic of China.
J Control Release. 2022 Apr;344:289-301. doi: 10.1016/j.jconrel.2022.01.034. Epub 2022 Jan 29.
Ferroptosis is an iron-dependent form of cell death accompanied by iron and lipid peroxidase accumulation and has drawn substantial attentions since its first discovery in 2012. Various studies have shown that tumor cells with high tumorigenicity, invasiveness, and metastatic potential are sensitive to ferroptosis. Consequently, many strategies to induce ferroptosis have been used in the design of antitumor nanodrug delivery systems (NDDSs). Prior reviews have thoroughly summarized the mechanism underlying ferroptosis, related pathways, and NDDSs materials. Recent studies have demonstrated that ferroptosis is interacted with several metabolic pathways, and these pathways have provided a basis for designing strategies for NDDSs-induced ferroptosis. Therefore, this review summarizes NDDSs designs for ferroptosis driven by different metabolic pathways, emphasizes the feasibility of inducing ferroptosis in cancer treatment, and finally discusses limitations of NDDSs and future developments in the field.
铁死亡是一种依赖铁的细胞死亡形式，伴随着铁和脂质过氧化物酶的积累，自 2012 年首次发现以来，引起了广泛关注。各种研究表明，具有高致瘤性、侵袭性和转移潜能的肿瘤细胞对铁死亡敏感。因此，许多诱导铁死亡的策略已被用于抗肿瘤纳米药物递送系统（NDDS）的设计。先前的综述详细总结了铁死亡的机制、相关途径和 NDDS 材料。最近的研究表明，铁死亡与几种代谢途径相互作用，这些途径为设计 NDDS 诱导铁死亡的策略提供了依据。因此，本综述总结了不同代谢途径驱动的 NDDS 设计用于铁死亡，强调了在癌症治疗中诱导铁死亡的可行性，最后讨论了 NDDS 的局限性和该领域的未来发展。
