Olejniczak Barbara, Balakrishnan Arpita, Augustyniak Justyna, Salińska Elżbieta, Bronisz Agnieszka, Godlewski Jakub
Department of Neurooncology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Translational Medicine Doctoral School, Centre of Postgraduate Medical Education, Warsaw, Poland.
Front Mol Neurosci. 2025 Apr 24;18:1576941. doi: 10.3389/fnmol.2025.1576941. eCollection 2025.
The transient receptor potential (TRP) gene family is vital to cellular physiology, mediating ion flow across membranes and facilitating sensory signal transduction. This article examines the transcriptomic landscape of TRP genes, emphasizing their varying expression across organs, tissues, and cells, with a particular focus on the brain. Analysis reveals a distinct spatial distribution of TRP gene expression, notably enriched in the hippocampus during brain development, highlighting their essential role in neuronal function. Utilizing datasets from the Human Protein Atlas, Allen Human Brain Atlas, and studies on aging and dementia, associations are identified between TRP gene expression and the development or pathophysiology of neural tissue, highlighting the therapeutic potential of TRP channels in addressing, e.g., sensory impairments and cognitive decline. These insights into the regulatory dynamics of TRP channels lay a foundation for developing targeted interventions for neurodegenerative disorders.
瞬时受体电位（TRP）基因家族对细胞生理学至关重要，介导离子跨膜流动并促进感觉信号转导。本文研究了TRP基因的转录组格局，强调了它们在器官、组织和细胞中的不同表达，尤其关注大脑。分析揭示了TRP基因表达的独特空间分布，在大脑发育过程中尤其在海马体中富集，突出了它们在神经元功能中的重要作用。利用来自人类蛋白质图谱、艾伦人类大脑图谱以及衰老和痴呆研究的数据集，确定了TRP基因表达与神经组织发育或病理生理学之间的关联，突出了TRP通道在解决例如感觉障碍和认知衰退方面的治疗潜力。这些对TRP通道调节动态的见解为开发针对神经退行性疾病的靶向干预措施奠定了基础。
