Inhibiting Serotonin Synthesis for the Treatment of Pulmonary Arterial Hypertension.
作者信息
Hansmann Georg, Bader Michael
机构信息
Department of Pediatric Cardiology Friedrich-Alexander-University Erlangen-Nürnberg Erlangen Germany.
European Pediatric Pulmonary Vascular Disease Network Berlin Germany.
出版信息
Pulm Circ. 2025 May 8;15(2):e70100. doi: 10.1002/pul2.70100. eCollection 2025 Apr.
Abstract
摘要
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本文引用的文献
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Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension.吸入新型色氨酸羟化酶1抑制剂TPT-004可缓解肺动脉高压。
Am J Respir Cell Mol Biol. 2025 Aug;73(2):288-298. doi: 10.1165/rcmb.2024-0365OC.
2
Safety and efficacy of rodatristat ethyl for the treatment of pulmonary arterial hypertension (ELEVATE-2): a dose-ranging, randomised, multicentre, phase 2b trial.罗沙司他乙酯治疗肺动脉高压的安全性和有效性（ELEVATE-2）：一项剂量范围、随机、多中心、2b 期临床试验。
Lancet Respir Med. 2024 Nov;12(11):865-876. doi: 10.1016/S2213-2600(24)00226-1. Epub 2024 Sep 19.
3
Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression.新型色氨酸羟化酶抑制剂TPT-001可逆转肺动脉高压、血管重塑以及增殖-促炎基因表达。
JACC Basic Transl Sci. 2024 Jun 5;9(7):890-902. doi: 10.1016/j.jacbts.2024.04.006. eCollection 2024 Jul.
4
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats.TPT-004，一种新一代色氨酸羟化酶抑制剂，可改善大鼠肺动脉高压。
J Am Heart Assoc. 2024 May 21;13(10):e034240. doi: 10.1161/JAHA.124.034240. Epub 2024 May 10.
5
Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension.色氨酸羟化酶1抑制对两种肺动脉高压大鼠模型肺血管重塑的影响
J Pharmacol Exp Ther. 2017 Feb;360(2):267-279. doi: 10.1124/jpet.116.237933. Epub 2016 Dec 7.
6
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.肺动脉高压的动物模型：病因发现与药物治疗的希望
Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1013-32. doi: 10.1152/ajplung.00217.2009. Epub 2009 Sep 11.
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Hypertension. 2007 Jan;49(1):232-6. doi: 10.1161/01.HYP.0000252210.58849.78. Epub 2006 Nov 27.
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