Amaral Camila Issa, Bezerra Lorena Santos, de Jesus Nascimento Acácia Eduarda, da Silva Nayara Toledo, Borges Lize Amanda Basaglia, da Silva Paloma Helena Sanches, Barbosa Letícia Monteiro, Nepomuceno Anelise Carvalho, Dos Santos Horta Rodrigo, Cassali Geovanni Dantas, Oliveira Ayisa Rodrigues
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Vet Res Commun. 2025 May 9;49(4):195. doi: 10.1007/s11259-025-10765-1.
A five-year-old neutered male domestic cat presented with a three-month history of vomiting, hyporexia, progressive weight loss, and abdominal pain. Ultrasound revealed a significant increase in the thickness of the ileum, suggestive of a neoplastic process. Enterectomy and enteroanastomosis was performed, and the sample was sent for histopathological examination. Grossly, the intestine was tortuous and was irregular. In the antimesenteric portion, a 1.4 cm thick, annular, homogenous, white and soft mass was present slightly reducing luminal diameter. Histologically, the neoplastic cells were arranged in sheets of large and pleomorphic round cells with numerous intracytoplasmic eosinophilic granules extending from the lamina propria to the serosa. Tumor cell immunolabelling was for CD3, multifocal for granzyme B and absent for CD79a and CD20. Based on the morphology and immunophenotyping of the neoplastic cells, the diagnosis of intestinal large granular lymphoma was made.
一只5岁已绝育的雄性家猫出现了3个月的呕吐、食欲减退、进行性体重减轻和腹痛病史。超声检查显示回肠厚度显著增加，提示存在肿瘤性病变。进行了肠切除术和肠吻合术，并将样本送去做组织病理学检查。大体上，肠道迂曲且不规则。在肠系膜对侧部分，有一个1.4厘米厚的环形、均匀、白色且柔软的肿块，使管腔直径略有减小。组织学上，肿瘤细胞排列成大片状的大的多形性圆形细胞，有许多胞浆内嗜酸性颗粒，从固有层延伸至浆膜。肿瘤细胞免疫标记显示CD3阳性，颗粒酶B多灶性阳性，CD79a和CD20阴性。根据肿瘤细胞的形态和免疫表型，诊断为肠道大颗粒淋巴瘤。
