职业性接触气溶胶与睡眠问题之间关系的调查：一项系统评价和荟萃分析。
Investigation of relationship between occupational exposure to aerosol and sleep problems: A systematic review and meta-analysis.
作者信息
Khoshakhlagh Amir Hossein, Yazdanirad Saeid, Gruszecka-Kosowska Agnieszka, Drake Christopher L, Emerson Wickwire
机构信息
Department of Occupational Health, School of Health, Kashan University of Medical Sciences, Kashan, Iran.
Department of Occupational Health, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
出版信息
PLoS One. 2025 May 9;20(5):e0321515. doi: 10.1371/journal.pone.0321515. eCollection 2025.
There are various occupational and industrial activities that are associated with the production of suspended particles. Little is known about sleep disturbance caused by exposure to aerosol exposure. Presented systematic review and meta-analysis study aimed to investigate the impact of various aerosols during occupational exposure on sleep. A systematic search in Scopus, Web of Science, PubMed, Embase, and Medline databases was performed until 20 February 2024. Three sets of keywords and their possible combinations were used in the search algorithm. To evaluate the quality and risk of bias in studies, the Joanna Briggs Institute (JBI) tools and risk of bias in non-randomized studies of exposure (ROBINS-E) instruments were applied, respectively. The pooled values were also computed by meta-analysis. Based on inclusion/exclusion criteria, 23 articles were entered into the review. 9 out of 11 articles with high quality (81.82 percent), 8 out of 9 articles with moderate quality (88.89 percent), and 2 out of 3 articles with low quality (66.67 percent) indicated that aerosol exposure had a meaningful negative effect on sleep among workers in various occupations. Among articles, 69.6% (N = 16) were given a high risk of bias rating, 13.0% (N = 3) were rated as moderate risk of bias, and 17.4% (N = 4) were rated as low risk of bias. The results of the meta-analysis indicated that the pooled value of the prevalence in the cross-sectional, cohort, and case control studies was 42.35 (95%CI [34.55, 50.16]), 10.82 (95%CI [6.76, 14.87]), and 35.70 (95%CI [13.96, 57.45]), respectively. Also, the results of the meta-analysis showed that the pooled values of the odds ratio in the cross-sectional and cohort studies were 1.82 (95% CI [1.43, 2.21]) and 1.73 (95% CI [1.49, 1.96]), respectively. Totally, most studies indicated that various sources of occupational aerosol exposure significantly affected sleep among employees.
有多种职业和工业活动与悬浮颗粒的产生有关。关于接触气溶胶导致睡眠障碍的情况，人们了解甚少。本系统评价和荟萃分析研究旨在调查职业接触期间各种气溶胶对睡眠的影响。截至2024年2月20日，在Scopus、科学网、PubMed、Embase和Medline数据库中进行了系统检索。在检索算法中使用了三组关键词及其可能的组合。为了评估研究的质量和偏倚风险，分别应用了乔安娜·布里格斯研究所（JBI）工具和非随机暴露研究中的偏倚风险（ROBINS-E）工具。汇总值也通过荟萃分析计算得出。根据纳入/排除标准，23篇文章进入综述。11篇高质量文章中有9篇（81.82%）、9篇中等质量文章中有8篇（88.89%）、3篇低质量文章中有2篇（66.67%）表明，气溶胶暴露对不同职业的工人的睡眠有显著负面影响。在这些文章中，69.6%（N = 16）被评为高偏倚风险等级，13.0%（N = 3）被评为中等偏倚风险等级，17.4%（N = 4）被评为低偏倚风险等级。荟萃分析结果表明，横断面研究、队列研究和病例对照研究中的患病率汇总值分别为42.35（95%CI [34.55, 50.16]）、10.82（95%CI [6.76, 14.87]）和35.70（95%CI [13.96, 57.45]）。此外，荟萃分析结果表明，横断面研究和队列研究中的优势比汇总值分别为1.82（95%CI [1.43, 2.21]）和1.73（95%CI [1.49, 1.96]）。总体而言，大多数研究表明，各种职业气溶胶暴露源对员工的睡眠有显著影响。
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