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What's new in Osmosin and intestinal perforation?

作者信息

Laidler P, Maslin S C, Gilhome R W

出版信息

Pathol Res Pract. 1985 Jul;180(1):74-6. doi: 10.1016/S0344-0338(85)80078-9.

Abstract

New formulations of drugs may have unexpected side effects. Osmosin is a new osmotic-pump controlled-release formulation of Indomethacin, designed to prevent gastrointestinal irritation. However, in a small number of cases the use of Osmosin has coincided with perforation of the small and large intestine, probably because passage of the tablet through the gastrointestinal tract was impeded.

摘要

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