Valderrama E, Kahn L B, Festa R, Lanzkowsky P
Pediatr Pathol. 1985;3(1):103-13. doi: 10.3109/15513818509068840.
Two cases of benign isolated cutaneous histiocytosis X in newborn infants are reported. Clinically, the lesions mimicked chicken pox, and the histologic findings in skin biopsies were indistinguishable from those described in infantile Letterer-Siwe disease. Electron microscopy showed Langerhans' cells with the classical trilaminar, racket-shaped granules. Our cases a well as 10 of the 21 previously reported cases showed spontaneous resolution of the skin lesions. Since this is a benign spontaneous resolving histiocytosis, we recommend that no therapy be given provided that no other signs of systemic involvement are found.
报告了两例新生儿良性孤立性皮肤组织细胞增多症X。临床上，皮损类似水痘，皮肤活检的组织学表现与婴儿勒-雪病中所描述的无法区分。电子显微镜显示朗格汉斯细胞具有典型的三层球拍状颗粒。我们的病例以及之前报告的21例中的10例显示皮损可自发消退。由于这是一种良性自限性组织细胞增多症，我们建议如果未发现其他全身受累迹象，则无需给予治疗。
