Palermo Maria Heloisa Rached, Pinto Michelli Barbara, Zanetti Juliana Silva, Ribeiro-Silva Alfredo
Alfredo Ribeiro-Silva, Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Bairro Monte Alegre, 14049-900, Ribeirão Preto, São Paulo, Brazil, tel. 55 16 3602 3172, fax 55 16 3633 1068, e-mail:
Pol J Pathol. 2013 Oct;64(3):210-5. doi: 10.5114/pjp.2013.38141.
Mucoepidermoid carcinomas in mammary glands represent 0.3% of all breast tumors. Features of salivary gland mucoepidermoid carcinoma have been used in studies concerning mucoepidermoid carcinomas of the breast because both share similar morphologic and molecular features. We report a case of primary mucoepidermoid carcinoma of the breast with an immunohistochemistry staining panel. We verified that MUC5AC occurs in more than 50% of high-grade tumors, and MUC1 correlates with shorter disease-free survival. The comparative analysis of mucin profiles may provide further insights into the clinical behavior of these tumors.
乳腺黏液表皮样癌占所有乳腺肿瘤的0.3%。由于乳腺黏液表皮样癌与涎腺黏液表皮样癌具有相似的形态学和分子特征，因此涎腺黏液表皮样癌的特征已被用于有关乳腺黏液表皮样癌的研究中。我们报告一例原发性乳腺黏液表皮样癌，并进行了免疫组织化学染色分析。我们证实，MUC5AC在超过50%的高级别肿瘤中出现，且MUC1与较短的无病生存期相关。黏蛋白谱的比较分析可能会为这些肿瘤的临床行为提供进一步的见解。
