Spratt J S, Spratt J A
Prog Clin Biol Res. 1985;186:103-20.
In summary, there is a wide, natural variance in rates of growth of benign and malignant neoplasms of the lower bowel. There is a crude correlation between growth rate and histopathology. The difference between DT(act) and DT(pot) is manifold. Primary surface desquamating cancers probably grow much slower than their metastases. These factors are of importance in understanding neoplastic behavior and in designing detection and treatment protocols. The gap in knowledge is for in vivo growth rates and mathematical patterns of growth in the period before a neoplasm reaches the threshold size permitting observation. The rates of growth are very relevant to screening and diagnostic strategies.
总之，下消化道良性和恶性肿瘤的生长速率存在广泛的自然差异。生长速率与组织病理学之间存在粗略的相关性。实际倍增时间（DT(act)）和潜在倍增时间（DT(pot)）之间的差异是多方面的。原发性表面脱屑性癌的生长可能比其转移瘤慢得多。这些因素对于理解肿瘤行为以及设计检测和治疗方案具有重要意义。在肿瘤达到可观察的阈值大小之前的体内生长速率和数学生长模式方面存在知识空白。生长速率与筛查和诊断策略密切相关。
