Ataman Sami, Girişgin Abdullah Sadık, Ayranci Mustafa Kürşat, Küçükceran Kadir
Emergency Department, Muradiye State Hospital, Van, Turkey.
Emergency Department, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
Sci Rep. 2025 May 9;15(1):16229. doi: 10.1038/s41598-025-00704-0.
There are no sufficient studies on laboratory parameters associated with acute stroke. Laboratory parameters associated with acute stroke may become important in the prevention or follow-up of the disease. To investigate the relationship between cerebrovascular disease (CVD) and serum phosphorus levels. This study was conducted prospectively to evaluate the relationship between cerebrovascular disease and phosphorus in patients who applied to the Emergency Medicine Clinic of the Faculty of Medicine Hospital and underwent central imaging between March 1, 2023, and December 31, 2023. 299 patients who applied to the university emergency department were prospectively included in the study with brain computed tomography (CT) and diffusion magnetic resonance imaging (MRI). The lactate, white blood cell, hgb, neutrophil, lymphocyte, urea, creatine and phosphorus values of the patients at their first admission were recorded. The patients were divided into two groups: CVD group and control group. The laboratory parameters of the patients were compared according to the groups. In the ROC analysis performed to evaluate the power of laboratory parameters in predicting the diagnosis of CVD, the AUC value of phosphorus was obtained as 0.935, lactate as 0.620 and urea as 0.596. The optimum cut-off value for phosphorus was calculated as 3.47 (mg/dl) and the sensitivity of this cut-off value was found to be 89%, specifically 86.9%, positive predictive value (ppv) as 77.4% and negative predictive value (npv) as 94%. Lactate, urea and phosphorus values were found to be significantly higher in the CVD group compared to the control group. With this study, we found that serum phosphorus levels were higher than our cut-off value in patients with acute ischemic CVD. We believe that serum phosphorus level will be useful in excluding acute cerebrovascular disease due to its high negative predictive value when evaluated according to the cut-off value of 3.47 (mg/dl).
关于与急性中风相关的实验室参数，目前尚无充分的研究。与急性中风相关的实验室参数在该疾病的预防或随访中可能变得很重要。为了研究脑血管疾病（CVD）与血清磷水平之间的关系。本研究前瞻性地评估了2023年3月1日至2023年12月31日期间到医学院医院急诊科就诊并接受中枢成像检查的患者中脑血管疾病与磷之间的关系。299名到大学急诊科就诊的患者通过脑部计算机断层扫描（CT）和扩散磁共振成像（MRI）被前瞻性地纳入研究。记录了患者首次入院时的乳酸、白细胞、血红蛋白、中性粒细胞、淋巴细胞、尿素、肌酐和磷值。患者被分为两组：CVD组和对照组。根据分组比较患者的实验室参数。在评估实验室参数预测CVD诊断能力的ROC分析中，磷的AUC值为0.935，乳酸为0.620，尿素为0.596。计算出磷的最佳截断值为3.47（mg/dl），该截断值的敏感性为89%，具体为86.9%，阳性预测值（ppv）为77.4%，阴性预测值（npv）为94%。发现CVD组的乳酸、尿素和磷值明显高于对照组。通过这项研究，我们发现急性缺血性CVD患者的血清磷水平高于我们的截断值。我们认为，根据3.47（mg/dl）的截断值评估时，血清磷水平因其高阴性预测值，将有助于排除急性脑血管疾病。
