Jiading District Center for Disease Control and Prevention, Shanghai, China.
Sci Rep. 2021 Apr 30;11(1):9366. doi: 10.1038/s41598-021-88127-5.
To explore distribution and epidemic characteristics of CVD in followed-up HP patients. Using the Hypertension Follow-up Management System database in Jiading district in Shanghai. We designed a retrospective cohort study that included all followed-up hypertension patients between 2002 and 2020. The endpoint was the occurrence of CVD confirmed by the hospital; otherwise, the patients were tracked until September 30, 2020. Record information of every patient has been collected in the registration card and each followed-up record. Among 223,097 observational followed-up HP patients, the total number of person years of observation was 4,244,421.25 person-year, 11,143 patients had developed CVD from hypertension before the deadline, the total incidence density was 0.00263 per person-year (male 0.00292; female 0.00238) and the complication ratio of CVD in HP patients was 4.99% (male 5.25%; female 4.76%) during follow-up period. The proportion of ischemic cerebrovascular, hemorrhagic cerebrovascular and unclassified stroke was respectively 71.18%, 5.95% and 22.87% in hypertensive CVD. Complication ratio of CVD increased with age, the group under 30 was 0, and the group over 70 was the highest (6.90%). The complication ratio of grad I, grad II and grad III blood pressure were respectively 4.79%, 4.96% and 6.13%. The complication ratio was 4.92% in only high systolic blood pressure patients; 17.23% in only high diastolic blood pressure patients; 4.59% in high systolic and diastolic blood pressure patients. The peak of complication ratio of CVD was 9-10 years after the registered and followed-up. The proportion of CVD cases in HP patients from April to June was the largest in the four seasons; the proportion of patients from October to December was the minimum. HP patient was prone to falling cerebrovascular disease; the main type of disease was cerebral infarction. Complication ratio in male incidence was higher than that in female. The complication ratio of CVD increased with age, blood pressure and duration of HP patients. It had seasonal characteristics, which was relatively high from April to June within year.
探讨随访高血压患者（HP）中 CVD 的分布和流行特征。我们使用上海市嘉定区高血压随访管理系统数据库，设计了一项回顾性队列研究，纳入了 2002 年至 2020 年间所有随访高血压患者。终点为医院确诊的 CVD 发生；否则，患者随访至 2020 年 9 月 30 日。每位患者的登记卡和每次随访记录均记录信息。在 223097 例观察性随访 HP 患者中，总观察人年数为 4244421.25 人年，11143 例患者在截止日期前因高血压并发 CVD，总发生率密度为 0.00263/人年（男性 0.00292；女性 0.00238），随访期间 HP 患者 CVD 的并发症比例为 4.99%（男性 5.25%；女性 4.76%）。高血压性 CVD 中缺血性脑卒中、出血性脑卒中及未分类脑卒中的比例分别为 71.18%、5.95%和 22.87%。CVD 的并发症比例随年龄增长而增加，30 岁以下组为 0，70 岁以上组最高（6.90%）。I 级、II 级和 III 级血压的并发症比例分别为 4.79%、4.96%和 6.13%。单纯收缩压升高患者的并发症比例为 4.92%；单纯舒张压升高患者为 17.23%；收缩压和舒张压均升高的患者为 4.59%。CVD 并发症的峰值出现在登记和随访后 9-10 年。HP 患者中 CVD 病例在 4 月至 6 月的比例在四季中最大，10 月至 12 月的比例最小。HP 患者易发生脑血管意外；主要疾病类型为脑梗死。男性的发病率高于女性。CVD 的并发症比例随 HP 患者的年龄、血压和病程的增加而增加。它具有季节性特征，年内 4 月至 6 月相对较高。
