Fundarò A, Molinengo L, Cassone M C
Pharmacol Res Commun. 1985 May;17(5):463-70. doi: 10.1016/0031-6989(85)90081-5.
The modification of behavior caused by hypo and hyperthyroidism were studied when the schedule of reinforcement was changed from a fixed ratio to a fixed interval. The conditions of hypo and hyperthyroidism were obtained with a chronic administration of methimazole and of 1-thyroxine. The level of the modifications of thyroid activity was determined by evaluation of the basal metabolic rate and of the plasma levels of T4. Hyperthyroidism caused no modification of the rat behaviour. A difficulty in adapting to the new experimental situation (learning) was found in hypothyroidism. This effect is evident in high hypothyroidism. In low hypothyroidism a depression of the rat behaviour may interfere with the modification of the learning process.
当强化程序从固定比率改为固定间隔时，研究了甲状腺功能减退和甲状腺功能亢进所引起的行为改变。通过长期给予甲巯咪唑和左旋甲状腺素分别造成甲状腺功能减退和甲状腺功能亢进的状态。通过评估基础代谢率和血浆T4水平来确定甲状腺活动改变的程度。甲状腺功能亢进未引起大鼠行为的改变。在甲状腺功能减退时发现大鼠难以适应新的实验情境（学习）。这种效应在严重甲状腺功能减退时很明显。在轻度甲状腺功能减退时，大鼠行为的抑制可能会干扰学习过程的改变。
